Mechanisms of Mycotoxin-induced Dermal Toxicity and Tumorigenesis Through Oxidative Stress-related Pathways

Overview

Journal J Toxicol Pathol

Date 2014 May 3

PMID 24791061

Citations 16

Authors

Kunio Doi

Koji Uetsuka

Affiliations

Soon will be listed here.

Abstract

Among the many mycotoxins, T-2 toxin, citrinin (CTN), patulin (PAT), aflatoxin B1 (AFB1) and ochratoxin A (OTA) are known to have the potential to induce dermal toxicity and/or tumorigenesis in rodent models. T-2 toxin, CTN, PAT and OTA induce apoptosis in mouse or rat skin. PAT, AFB1 and OTA have tumor initiating properties, and OTA is also a tumor promoter in mouse skin. This paper reviews the molecular mechanisms of dermal toxicity and tumorigenesis induced in rodent models by these mycotoxins especially from the viewpoint of oxidative stress-mediated pathways.

Citing Articles

Advances in Antitumor Effects Using Liposomal Citrinin in Induced Breast Cancer Model.

Moura M, de Menezes A, Oliveira Filho J, do Nascimento M, Dos Reis A, Ribeiro A Pharmaceutics. 2024; 16(2).

PMID: 38399235 PMC: 10892831. DOI: 10.3390/pharmaceutics16020174.

Preventive role of cinnamaldehyde against tenuazonic acid- and Freund's adjuvant-induced histopathological and biochemical alterations in the mouse model.

Kumari A, Singh K Front Microbiol. 2023; 14:1159881.

PMID: 37426034 PMC: 10325827. DOI: 10.3389/fmicb.2023.1159881.

Detoxication of Citrinin with Kojic Acid by the Formation of the Citrinin-Kojic Acid Adduct, and the Enhancement of Kojic Acid Production by Citrinin via Oxidative Stress in Aspergillus parasiticus.

Ichinomiya M, Kawamoto A, Yamaguchi T, Iwashita K, Nagashima H, Hatabayashi H J Fungi (Basel). 2023; 9(1).

PMID: 36675872 PMC: 9863397. DOI: 10.3390/jof9010051.

-Acetylcysteine Inhibits Patulin-Induced Apoptosis by Affecting ROS-Mediated Oxidative Damage Pathway.

Liu J, Liu Q, Han J, Feng J, Guo T, Li Z Toxins (Basel). 2021; 13(9).

PMID: 34564600 PMC: 8473236. DOI: 10.3390/toxins13090595.

Aflatoxin Biosynthesis, Genetic Regulation, Toxicity, and Control Strategies: A Review.

Khan R, Ghazali F, Mahyudin N, Samsudin N J Fungi (Basel). 2021; 7(8).

PMID: 34436145 PMC: 8397101. DOI: 10.3390/jof7080606.

References

Ferrarini M, Heltai S, Zocchi M, RUGARLI C . Unusual expression and localization of heat-shock proteins in human tumor cells. Int J Cancer. 1992; 51(4):613-9. DOI: 10.1002/ijc.2910510418. View

Riley R, Kemppainen B, Norred W . Penetration of aflatoxins through isolated human epidermis. J Toxicol Environ Health. 1985; 15(6):769-77. DOI: 10.1080/15287398509530703. View

Pfohl-Leszkowicz A, Chakor K, Creppy E, DIRHEIMER G . DNA adduct formation in mice treated with ochratoxin A. IARC Sci Publ. 1991; (115):245-53. View

Kitabatake N, Doi E, Trivedi A . Toxicity evaluation of the mycotoxins, citrinin and ochratoxin A, using several animal cell lines. Comp Biochem Physiol C Comp Pharmacol Toxicol. 1993; 105(3):429-33. DOI: 10.1016/0742-8413(93)90082-v. View

Barker J, Mitra R, Griffiths C, Dixit V, Nickoloff B . Keratinocytes as initiators of inflammation. Lancet. 1991; 337(8735):211-4. DOI: 10.1016/0140-6736(91)92168-2. View

Kensler T, Wakabayashi N, Biswal S . Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol. 2006; 47:89-116. DOI: 10.1146/annurev.pharmtox.46.120604.141046. View

Lea T, Steien K, Stormer F . Mechanism of ochratoxin A-induced immunosuppression. Mycopathologia. 1989; 107(2-3):153-9. DOI: 10.1007/BF00707553. View

Karthikeyan K, Ravichandran P, Govindasamy S . Chemopreventive effect of Ocimum sanctum on DMBA-induced hamster buccal pouch carcinogenesis. Oral Oncol. 1999; 35(1):112-9. DOI: 10.1016/s1368-8375(98)00035-9. View

Shifrin V, Anderson P . Trichothecene mycotoxins trigger a ribotoxic stress response that activates c-Jun N-terminal kinase and p38 mitogen-activated protein kinase and induces apoptosis. J Biol Chem. 1999; 274(20):13985-92. DOI: 10.1074/jbc.274.20.13985. View

10.

Iwamoto S, Nakayama H, Doi K . Morphological and morphometrical study on the dorsal skin of Wistar and WBN/ILA-Ht rats in their developing stage. Evaluation of the proliferation and apoptotic processes. Histol Histopathol. 1998; 13(4):981-8. DOI: 10.14670/HH-13.981. View

11.

Nickoloff B, Naidu Y . Perturbation of epidermal barrier function correlates with initiation of cytokine cascade in human skin. J Am Acad Dermatol. 1994; 30(4):535-46. DOI: 10.1016/s0190-9622(94)70059-1. View

12.

Bunner B, Wannemacher Jr R, Dinterman R, Broski F . Cutaneous absorption and decontamination of [3H]T-2 toxin in the rat model. J Toxicol Environ Health. 1989; 26(4):413-23. DOI: 10.1080/15287398909531265. View

13.

Chan W . Citrinin induces apoptosis in mouse embryonic stem cells. IUBMB Life. 2008; 60(3):171-9. DOI: 10.1002/iub.30. View

14.

Malcotti V, Yasoshima A, Imaoka K, Nakayama H, Doi K . Dorsal skin responses to subchronic ultraviolet B (UVB)-irradiation in Wistar-derived hypotrichotic WBN/ILA-Ht rats. Histol Histopathol. 2002; 17(3):683-90. DOI: 10.14670/HH-17.683. View

15.

Robles A, Conti C . Early overexpression of cyclin D1 protein in mouse skin carcinogenesis. Carcinogenesis. 1995; 16(4):781-6. DOI: 10.1093/carcin/16.4.781. View

16.

Albarenque S, Suzuki K, Shinozuka J, Nakayama H, Doi K . Kinetics of apoptosis-related genes mRNA expression in the dorsal skin of hypotrichotic WBN/ILA-ht rats after topical application of T-2 toxin. Exp Toxicol Pathol. 2001; 52(6):553-6. DOI: 10.1016/s0940-2993(01)80016-6. View

17.

Boonen J, Malysheva S, Taevernier L, Diana Di Mavungu J, De Saeger S, De Spiegeleer B . Human skin penetration of selected model mycotoxins. Toxicology. 2012; 301(1-3):21-32. DOI: 10.1016/j.tox.2012.06.012. View

18.

Sehata S, Kiyosawa N, Makino T, Atsumi F, Ito K, Yamoto T . Morphological and microarray analysis of T-2 toxin-induced rat fetal brain lesion. Food Chem Toxicol. 2004; 42(11):1727-36. DOI: 10.1016/j.fct.2004.06.006. View

19.

Arora R, FROLEN H . Inhibition of ochratoxin A teratogenesis by zearalenone and diethylstilboestrol. Food Chem Toxicol. 1983; 21(6):779-83. DOI: 10.1016/0278-6915(83)90212-0. View

20.

Amstad P, Levy A, Emerit I, Cerutti P . Evidence for membrane-mediated chromosomal damage by aflatoxin B1 in human lymphocytes. Carcinogenesis. 1984; 5(6):719-23. DOI: 10.1093/carcin/5.6.719. View