Data on How Several Physiological Parameters of Stored Red Blood Cells Are Similar in Glucose 6-phosphate Dehydrogenase Deficient and Sufficient Donors

Overview

Journal Data Brief

Date 2016 Jul 21

PMID 27437434

Citations 13

Authors

Vassilis L Tzounakas

Anastasios G Kriebardis

Hara T Georgatzakou

Leontini E Foudoulaki-Paparizos

Monika Dzieciatkowska

Matthew J Wither

Travis Nemkov

Kirk C Hansen

Issidora S Papassideri

Angelo DAlessandro

Marianna H Antonelou

Affiliations

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Abstract

This article contains data on the variation in several physiological parameters of red blood cells (RBCs) donated by eligible glucose-6-phosphate dehydrogenase (G6PD) deficient donors during storage in standard blood bank conditions compared to control, G6PD sufficient (G6PD(+)) cells. Intracellular reactive oxygen species (ROS) generation, cell fragility and membrane exovesiculation were measured in RBCs throughout the storage period, with or without stimulation by oxidants, supplementation of N-acetylcysteine and energy depletion, following incubation of stored cells for 24 h at 37 °C. Apart from cell characteristics, the total or uric acid-dependent antioxidant capacity of the supernatant in addition to extracellular potassium concentration was determined in RBC units. Finally, procoagulant activity and protein carbonylation levels were measured in the microparticles population. Further information can be found in "Glucose 6-phosphate dehydrogenase deficient subjects may be better "storers" than donors of red blood cells" [1].

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Red Blood Cell Metabolism In Vivo and In Vitro.

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References

DAlessandro A, Nemkov T, Hansen K, Szczepiorkowski Z, Dumont L . Red blood cell storage in additive solution-7 preserves energy and redox metabolism: a metabolomics approach. Transfusion. 2015; 55(12):2955-66. PMC: 5823509. DOI: 10.1111/trf.13253. View

Kriebardis A, Antonelou M, Stamoulis K, Economou-Petersen E, Margaritis L, Papassideri I . Membrane protein carbonylation in non-leukodepleted CPDA-preserved red blood cells. Blood Cells Mol Dis. 2006; 36(2):279-82. DOI: 10.1016/j.bcmd.2006.01.003. View

Raval J, Waters J, Seltsam A, Scharberg E, Richter E, Daly A . The use of the mechanical fragility test in evaluating sublethal RBC injury during storage. Vox Sang. 2010; 99(4):325-31. DOI: 10.1111/j.1423-0410.2010.01365.x. View

Antonelou M, Tzounakas V, Velentzas A, Stamoulis K, Kriebardis A, Papassideri I . Effects of pre-storage leukoreduction on stored red blood cells signaling: a time-course evaluation from shape to proteome. J Proteomics. 2012; 76 Spec No.:220-38. DOI: 10.1016/j.jprot.2012.06.032. View

DAlessandro A, Nemkov T, Kelher M, West F, Schwindt R, Banerjee A . Routine storage of red blood cell (RBC) units in additive solution-3: a comprehensive investigation of the RBC metabolome. Transfusion. 2015; 55(6):1155-68. PMC: 4469527. DOI: 10.1111/trf.12975. View

Tzounakas V, Kriebardis A, Georgatzakou H, Foudoulaki-Paparizos L, Dzieciatkowska M, Wither M . Glucose 6-phosphate dehydrogenase deficient subjects may be better "storers" than donors of red blood cells. Free Radic Biol Med. 2016; 96:152-65. DOI: 10.1016/j.freeradbiomed.2016.04.005. View

Kraus A, Roth H, Kirchgessner M . Supplementation with vitamin C, vitamin E or beta-carotene influences osmotic fragility and oxidative damage of erythrocytes of zinc-deficient rats. J Nutr. 1997; 127(7):1290-6. DOI: 10.1093/jn/127.7.1290. View

Duplancic D, Kukoc-Modun L, Modun D, Radic N . Simple and rapid method for the determination of uric acid-independent antioxidant capacity. Molecules. 2011; 16(8):7058-68. PMC: 6264207. DOI: 10.3390/molecules16087058. View

Kriebardis A, Antonelou M, Georgatzakou H, Tzounakas V, Stamoulis K, Papassideri I . Microparticles variability in fresh frozen plasma: preparation protocol and storage time effects. Blood Transfus. 2016; 14(2):228-37. PMC: 4918554. DOI: 10.2450/2016.0179-15. View

10.

Benzie I, Strain J . The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. Anal Biochem. 1996; 239(1):70-6. DOI: 10.1006/abio.1996.0292. View

11.

HARBOE M . A method for determination of hemoglobin in plasma by near-ultraviolet spectrophotometry. Scand J Clin Lab Invest. 1959; 11:66-70. DOI: 10.3109/00365515909060410. View