Role of Lipids in the Metabolism and Activation of Immune Cells

Overview

Journal J Nutr Biochem

Specialties Biochemistry
Nutritional Sciences

Date 2016 Jul 18

PMID 27424223

Citations 108

Authors

Merla J Hubler

Arion J Kennedy

Affiliations

Soon will be listed here.

Abstract

Immune cell plasticity has extensive implications in the pathogenesis and resolution of metabolic disorders, cancers, autoimmune diseases and chronic inflammatory disorders. Over the past decade, nutritional status has been discovered to influence the immune response. In metabolic disorders such as obesity, immune cells interact with various classes of lipids, which are capable of controlling the plasticity of macrophages and T lymphocytes. The purpose of this review is to discuss lipids and their impact on innate and adaptive immune responses, focusing on two areas: (1) the impact of altering lipid metabolism on immune cell activation, differentiation and function and (2) the mechanism by which lipids such as cholesterol and fatty acids regulate immune cell plasticity.

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