Small Extracellular Vesicles in the Pericardium Modulate Macrophage Immunophenotype in Coronary Artery Disease

Overview

Journal JACC Basic Transl Sci

Date 2024 Oct 24

PMID 39444932

Authors

Soumaya Ben-Aicha

Maryam Anwar

Gemma Vilahur

Fabiana Martino

Panagiotis G Kyriazis

Natasha de Winter

Prakash P Punjabi

Gianni D Angelini

Susanne Sattler

Costanza Emanueli

Affiliations

Soon will be listed here.

Abstract

Coronary artery disease (CAD) is a major health issue. This study focused on pericardial macrophages and small extracellular vesicles (sEVs) in CAD. The macrophages in CAD patients showed reduced expression of protective markers and unchanged levels of proinflammatory receptors. Similar changes were observed in buffy-coat-derived macrophages when stimulated with CAD pericardial fluid-derived sEVs. The sEV contained miRNA-6516-5p, which inhibited CD36 and affected macrophage lipid uptake. These findings indicate that sEV-mediated miRNA actions contribute to the decrease in protective pericardial macrophages in CAD.

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