Facile Construction of 2-pyrones Under Carbene Catalysis

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2024 Sep 9

PMID 39247504

Authors

Miao Yu

Jie Huang

Haibin Zhu

Dongping Shi

Weiqi Yang

Yingjie Liu

Yubin Ji

Zhenqian Fu

Affiliations

Soon will be listed here.

Abstract

2-Pyrones are valuable structural motifs in organic chemistry, found in numerous natural products and pharmaceuticals. The synthesis of these heterocycles has been significantly advanced by the application of N-Heterocyclic Carbene (NHC) catalysis. This review examines the recent advancements in NHC-catalyzed synthesis of 2-pyrones, highlighting key methodologies, mechanisms, and synthetic applications. NHC catalysis has revolutionized the synthesis of 2-pyrones, providing efficient, selective, and versatile methods for constructing these valuable heterocycles.

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