Periostin and Interleukin-13 Are Independently Related to Chronic Spontaneous Urticaria

Overview

Journal Allergy Asthma Immunol Res

Date 2016 Jun 24

PMID 27334784

Citations 10

Authors

Youin Bae

Kenji Izuhara

Soichiro Ohta

Junya Ono

Gwan Ui Hong

Jai Youl Ro

Gyeong Hun Park

Jeong Hee Choi

Affiliations

Soon will be listed here.

Abstract

Chronic spontaneous urticaria (CSU) is a complex idiopathic disease of the skin with various cellular infiltrations. Although mast cells are key effector cells in the pathogenesis of CSU, CD4+ T helper 2 cells also have particular roles in the development and maintenance of CSU. Periostin is known as a downstream molecule of interleukin (IL)-4 and IL-13, key cytokines of type 2 immune responses. In this study, we examined periostin and IL-13 levels in the sera of patients with CSU (n=84) and healthy normal controls (NCs, n=43). Periostin levels were significantly lower in the CSU group than in NCs (71.4±21.8 vs 85.1±22.4 ng/mL, P=0.04). Periostin levels were also lower in the severe CSU group than those in mild CSU (59.7±18.0 vs 73.4±22.0 ng/mL, P=0.04). However, IL-13 levels were significantly higher in patients with CSU than in NCs (508.5±51.2 vs 200.7±13.3 pg/mL, P=0.001). In conclusion, periostin and IL-13 may be independently related to the pathogenesis of CSU.

Citing Articles

Atopy in chronic urticaria: an important yet overlooked issue.

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Identification of Immune Cell-Types and Pathways Involved in Chronic Spontaneous Urticaria.

Prosty C, Gabrielli S, Ben-Shoshan M, Le M, Gimenez-Arnau A, Litvinov I Front Med (Lausanne). 2022; 9:926753.

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The Role of Crosstalk of Immune Cells in Pathogenesis of Chronic Spontaneous Urticaria.

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Exhaled Nitric Oxide Level in Pharynx Angioedema.

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Periostin in Allergy and Inflammation.

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