Mediators of Inflammation and Angiogenesis in Chronic Spontaneous Urticaria: Are They Potential Biomarkers of the Disease?

Overview

Journal Mediators Inflamm

Publisher Wiley

Specialties Biochemistry
Pathology

Date 2017 Oct 18

PMID 29038618

Citations 14

Authors

Ilaria Puxeddu

Federico Pratesi

Domenico Ribatti

Paola Migliorini

Affiliations

Soon will be listed here.

Abstract

In chronic spontaneous urticaria (CSU), different pathophysiological mechanisms, potentially responsible for the development of the disease, have been recently described. It is likely that the activation of skin mast cells with consequent release of histamine and other proinflammatory mediators is responsible for vasodilation in the lesional skin of CSU. However, the underlying causes of mast cell activation in the disease are largely unknown and remain to be identified. Thus, in this review, we discuss new insights in the pathogenesis of CSU, focusing on inflammation and angiogenesis. The understanding of these mechanisms will enable the identification of biomarkers useful for the diagnosis, follow-up, and management of CSU and will allow the development of novel, more specific, and patient-tailored therapies.

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References

Puxeddu I, Piliponsky A, Bachelet I, Levi-Schaffer F . Mast cells in allergy and beyond. Int J Biochem Cell Biol. 2003; 35(12):1601-7. DOI: 10.1016/s1357-2725(03)00208-5. View

Dilek F, Ozceker D, Ozkaya E, Tamay Z, Yazici M, Kesgin S . Plasma Levels of Matrix Metalloproteinase-9 in Children With Chronic Spontaneous Urticaria. Allergy Asthma Immunol Res. 2016; 8(6):522-6. PMC: 5011052. DOI: 10.4168/aair.2016.8.6.522. View

Bae Y, Izuhara K, Ohta S, Ono J, Hong G, Ro J . Periostin and Interleukin-13 Are Independently Related to Chronic Spontaneous Urticaria. Allergy Asthma Immunol Res. 2016; 8(5):457-60. PMC: 4921700. DOI: 10.4168/aair.2016.8.5.457. View

Kurt E, Aktas A, Aksu K, Keren M, Dokumacioglu A, Goss C . Autologous serum skin test response in chronic spontaneous urticaria and respiratory diseases and its relationship with serum interleukin-18 level. Arch Dermatol Res. 2011; 303(9):643-9. DOI: 10.1007/s00403-011-1144-x. View

Vohra S, Sharma N, Mahajan V, Shanker V . Clinicoepidemiologic features of chronic urticaria in patients having positive versus negative autologous serum skin test: a study of 100 Indian patients. Indian J Dermatol Venereol Leprol. 2011; 77(2):156-9. DOI: 10.4103/0378-6323.77454. View

Bingham 3rd C . Immunomodulatory approaches to the management of chronic urticaria: an immune-mediated inflammatory disease. Curr Allergy Asthma Rep. 2008; 8(4):278-87. DOI: 10.1007/s11882-008-0046-2. View

Sabroe R, Francis D, Barr R, BLACK A, Greaves M . Anti-Fc(episilon)RI auto antibodies and basophil histamine releasability in chronic idiopathic urticaria. J Allergy Clin Immunol. 1998; 102(4 Pt 1):651-8. DOI: 10.1016/s0091-6749(98)70283-0. View

Asero R, Tedeschi A, Marzano A, Cugno M . Chronic spontaneous urticaria: immune system, blood coagulation, and more. Expert Rev Clin Immunol. 2015; 12(3):229-31. DOI: 10.1586/1744666X.2016.1127160. View

Migliorini P, Anzilotti C, Pratesi F, Quattroni P, Bargagna M, Dinarello C . Serum and urinary levels of IL-18 and its inhibitor IL-18BP in systemic lupus erythematosus. Eur Cytokine Netw. 2010; 21(4):264-71. DOI: 10.1684/ecn.2010.0210. View

10.

Folkman J . Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med. 1995; 1(1):27-31. DOI: 10.1038/nm0195-27. View

11.

Kasperska-Zajac A . Acute-phase response in chronic urticaria. J Eur Acad Dermatol Venereol. 2011; 26(6):665-72. DOI: 10.1111/j.1468-3083.2011.04366.x. View

12.

Tedeschi A, Asero R, Lorini M, Marzano A, Cugno M . Plasma levels of matrix metalloproteinase-9 in chronic urticaria patients correlate with disease severity and C-reactive protein but not with circulating histamine-releasing factors. Clin Exp Allergy. 2010; 40(6):875-81. DOI: 10.1111/j.1365-2222.2010.03473.x. View

13.

Grattan C, Dawn G, Gibbs S, Francis D . Blood basophil numbers in chronic ordinary urticaria and healthy controls: diurnal variation, influence of loratadine and prednisolone and relationship to disease activity. Clin Exp Allergy. 2003; 33(3):337-41. DOI: 10.1046/j.1365-2222.2003.01589.x. View

14.

Tedeschi A, Lorini M, Suli C, Asero R . Serum interleukin-18 in patients with chronic ordinary urticaria: association with disease activity. Clin Exp Dermatol. 2007; 32(5):568-70. DOI: 10.1111/j.1365-2230.2007.02450.x. View

15.

Pastore S, Mascia F, Mariotti F, Dattilo C, Girolomoni G . Chemokine networks in inflammatory skin diseases. Eur J Dermatol. 2004; 14(4):203-8. View

16.

Risau W . Mechanisms of angiogenesis. Nature. 1997; 386(6626):671-4. DOI: 10.1038/386671a0. View

17.

Wenzel D, Schmidt A, Reimann K, Hescheler J, Pfitzer G, Bloch W . Endostatin, the proteolytic fragment of collagen XVIII, induces vasorelaxation. Circ Res. 2006; 98(9):1203-11. DOI: 10.1161/01.RES.0000219899.93384.ed. View

18.

Tedeschi A, Asero R, Marzano A, Lorini M, Fanoni D, Berti E . Plasma levels and skin-eosinophil-expression of vascular endothelial growth factor in patients with chronic urticaria. Allergy. 2009; 64(11):1616-22. DOI: 10.1111/j.1398-9995.2009.02069.x. View

19.

Kasperska-Zajac A, Grzanka A, Misiolek M, Mazur B, Machura E . Pentraxin-3 as a local inflammatory marker in chronic spontaneous urticaria. Cytokine. 2015; 76(2):566-568. DOI: 10.1016/j.cyto.2015.04.016. View

20.

Burger D, Touyz R . Cellular biomarkers of endothelial health: microparticles, endothelial progenitor cells, and circulating endothelial cells. J Am Soc Hypertens. 2012; 6(2):85-99. DOI: 10.1016/j.jash.2011.11.003. View