Is There Potential for Repurposing Statins As Novel Antimicrobials?

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2016 Jun 22

PMID 27324773

Citations 60

Authors

Emma Hennessy

Claire Adams

F Jerry Reen

Fergal OGara

Affiliations

Soon will be listed here.

Abstract

Statins are members of a class of pharmaceutical widely used to reduce high levels of serum cholesterol. In addition, statins have so-called "pleiotropic effects," which include inflammation reduction, immunomodulation, and antimicrobial effects. An increasing number of studies are emerging which detail the attenuation of bacterial growth and in vitro and in vivo virulence by statin treatment. In this review, we describe the current information available concerning the effects of statins on bacterial infections and provide insight regarding the potential use of these compounds as antimicrobial therapeutic agents.

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