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Regulation of the Mevalonate Pathway

Overview
Journal Nature
Specialty Science
Date 1990 Feb 1
PMID 1967820
Citations 1465
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Abstract

The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions, ranging from cholesterol synthesis to growth control. Several mechanisms for feedback regulation of low-density-lipoprotein receptors and of two enzymes involved in mevalonate biosynthesis ensure the production of sufficient mevalonate for several end-products. Manipulation of this regulatory system could be useful in treating certain forms of cancer as well as heart disease.

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