Endoplasmic Reticulum-Associated Degradation and Lipid Homeostasis

Overview

Journal Annu Rev Nutr

Publisher Annual Reviews

Specialty Nutritional Sciences

Date 2016 Jun 15

PMID 27296502

Citations 83

Authors

Julian Stevenson

Edmond Y Huang

James A Olzmann

Affiliations

Soon will be listed here.

Abstract

The endoplasmic reticulum is the port of entry for proteins into the secretory pathway and the site of synthesis for several important lipids, including cholesterol, triacylglycerol, and phospholipids. Protein production within the endoplasmic reticulum is tightly regulated by a cohort of resident machinery that coordinates the folding, modification, and deployment of secreted and integral membrane proteins. Proteins failing to attain their native conformation are degraded through the endoplasmic reticulum-associated degradation (ERAD) pathway via a series of tightly coupled steps: substrate recognition, dislocation, and ubiquitin-dependent proteasomal destruction. The same ERAD machinery also controls the flux through various metabolic pathways by coupling the turnover of metabolic enzymes to the levels of key metabolites. We review the current understanding and biological significance of ERAD-mediated regulation of lipid metabolism in mammalian cells.

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