CEACAM1-Mediated Inhibition of Virus Production

Overview

Journal Cell Rep

Publisher Cell Press

Specialties Biology
Cell Biology
Molecular Biology

Date 2016 Jun 7

PMID 27264178

Citations 18

Authors

Alon Vitenshtein

Yiska Weisblum

Sebastian Hauka

Anne Halenius

Esther Oiknine-Djian

Pinchas Tsukerman

Yoav Bauman

Yotam Bar-On

Noam Stern-Ginossar

Jonatan Enk

Rona Ortenberg

Julie Tai

Gal Markel

Richard S Blumberg

Hartmut Hengel

Stipan Jonjic

Dana G Wolf

Heiko Adler

Robert Kammerer

Ofer Mandelboim

Affiliations

Soon will be listed here.

Abstract

Cells in our body can induce hundreds of antiviral genes following virus sensing, many of which remain largely uncharacterized. CEACAM1 has been previously shown to be induced by various innate systems; however, the reason for such tight integration to innate sensing systems was not apparent. Here, we show that CEACAM1 is induced following detection of HCMV and influenza viruses by their respective DNA and RNA innate sensors, IFI16 and RIG-I. This induction is mediated by IRF3, which bound to an ISRE element present in the human, but not mouse, CEACAM1 promoter. Furthermore, we demonstrate that, upon induction, CEACAM1 suppresses both HCMV and influenza viruses in an SHP2-dependent process and achieves this broad antiviral efficacy by suppressing mTOR-mediated protein biosynthesis. Finally, we show that CEACAM1 also inhibits viral spread in ex vivo human decidua organ culture.

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