Ofer Mandelboim
Overview
Explore the profile of Ofer Mandelboim including associated specialties, affiliations and a list of published articles.
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Articles
225
Citations
10831
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Recent Articles
1.
Charpak-Amikam Y, Kournos M, Kotzur R, Isaacson B, Bagad Brenner T, Gomez-Cesar E, et al.
Nat Commun
. 2024 Oct;
15(1):8664.
PMID: 39375344
NKG2D is a central activating receptor involved in target recognition and killing by Natural Killer and CD8 T cells. The known role of NKG2D is to recognize a family of...
2.
Rishiq A, Liu M, Mandelboim O
mBio
. 2024 Aug;
15(9):e0116524.
PMID: 39109867
Importance: Our results identify the significance of T cell immunoreceptor with immunoglobulin and ITIM domain in modulating host defense against and highlight the potential therapeutic implications for infections.
3.
Galaski J, Rishiq A, Liu M, Bsoul R, Bergson A, Lux R, et al.
iScience
. 2024 Jul;
27(6):110157.
PMID: 38952680
is an oral commensal bacterium that can colonize extraoral tumor entities, such as colorectal cancer and breast cancer. Recent studies revealed its ability to modulate the immune response in the...
4.
Kotzur R, Kahlon S, Isaacson B, Gamliel M, Charpak-Amikam Y, Lieberman J, et al.
PLoS Pathog
. 2024 Jan;
20(1):e1011923.
PMID: 38215172
Natural killer cells (NKs) found during pregnancy at the maternal-fetal interface named decidual (d)NKs, show signs of education following first pregnancy, resulting in better placentation and fetus-growth, hence termed pregnancy...
5.
Blumke J, Bauer M, Vaxevanis C, Wilfer A, Mandelboim O, Wickenhauser C, et al.
Oncoimmunology
. 2023 Dec;
12(1):2284483.
PMID: 38126030
The human Epstein-Barr virus (EBV), as a member of the human γ herpes viruses (HHV), is known to be linked with distinct tumor types. It is a double-stranded DNA virus...
6.
Kotzur R, Stein N, Kahlon S, Berhani O, Isaacson B, Mandelboim O
iScience
. 2023 Aug;
26(8):107284.
PMID: 37609636
Natural killer (NK) cells are currently used in clinical trials to treat tumors. However, such therapies still suffer from problems such as donor variability, reproducibility, and more, which prevent a...
7.
Gaur P, Seaf M, Trabelsi N, Marcu O, Gafarov D, Schueler-Furman O, et al.
Clin Exp Immunol
. 2023 Aug;
215(1):37-46.
PMID: 37583293
Staphylococcus aureus (SA) and its exotoxins activate eosinophils (Eos) and mast cells (MCs) via CD48, a GPI-anchored receptor belonging to the signaling lymphocytes activation molecules (SLAM) family. 2B4 (CD244), an...
8.
Kol I, Rishiq A, Cohen M, Kahlon S, Pick O, Dassa L, et al.
J Cell Biol
. 2023 Jun;
222(9).
PMID: 37389656
The GPI-anchoring pathway plays important roles in normal development and immune modulation. MHC Class I Polypeptide-related Sequence A (MICA) is a stress-induced ligand, downregulated by human cytomegalovirus (HCMV) to escape...
9.
Rishiq A, Bsoul R, Pick O, Mandelboim O
Oncoimmunology
. 2023 Jun;
12(1):2217735.
PMID: 37261087
The use of antibodies to block inhibitory receptors, primarily anti-PD1 and CTLA4 (known as checkpoint therapy) revolutionized cancer treatment. However, despite these successes, the majority of cancer patients do not...
10.
Derivation and Preclinical Characterization of CYT-303, a Novel NKp46-NK Cell Engager Targeting GPC3
Arulanandam A, Lin L, Chang H, Cerutti M, Choblet S, Gao P, et al.
Cells
. 2023 Apr;
12(7).
PMID: 37048069
Glypican-3 (GPC3) is an oncofetal antigen that is highly expressed in multiple solid tumors, including hepatocellular carcinoma, and is barely expressed in adult normal tissues except the placenta. NKp46 activation...