Baicalein Protects Human Skin Cells Against Ultraviolet B-Induced Oxidative Stress

Overview

Journal Biomol Ther (Seoul)

Specialty Pharmacology

Date 2016 Jun 4

PMID 27257012

Citations 16

Authors

Min Chang Oh

Mei Jing Piao

Pattage Madushan Dilhara Jayatissa Fernando

Xia Han

Susara Ruwan Kumara Madduma Hewage

Jeong Eon Park

Mi Sung Ko

Uhee Jung

In Gyu Kim

Jin Won Hyun

Affiliations

Soon will be listed here.

Abstract

Baicalein (5,6,7-trihydroxy-2-phenyl-chromen-4-one) is a flavone, a type of flavonoid, originally isolated from the roots of . This study evaluated the protective effects of baicalein against oxidative damage-mediated apoptosis induced by ultraviolet B (UVB) radiation in a human keratinocyte cell line (HaCaT). Baicalein absorbed light within the wavelength range of UVB. In addition, baicalein decreased the level of intracellular reactive oxygen species (ROS) in response to UVB radiation. Baicalein protected cells against UVB radiation-induced DNA breaks, 8-isoprostane generation and protein modification in HaCaT cells. Furthermore, baicalein suppressed the apoptotic cell death by UVB radiation. These findings suggest that baicalein protected HaCaT cells against UVB radiation-induced cell damage and apoptosis by absorbing UVB radiation and scavenging ROS.

Citing Articles

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Chemical Characterization and Determination of the Antioxidant Properties of Phenolic Compounds in Three sp. Plants Grown in Colombia.

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The Cytoprotective Effects of Baicalein on HO-Induced ROS by Maintaining Mitochondrial Homeostasis and Cellular Tight Junction in HaCaT Keratinocytes.

Kim G, Han D, Lee J Antioxidants (Basel). 2023; 12(4).

PMID: 37107277 PMC: 10135986. DOI: 10.3390/antiox12040902.

Baicalein Induces G/M Cell Cycle Arrest Associated with ROS Generation and CHK2 Activation in Highly Invasive Human Ovarian Cancer Cells.

Chuang T, Shao W, Hsu S, Lee S, Kao M, Wang V Molecules. 2023; 28(3).

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Protective and therapeutic effects of Scutellaria baicalensis and its main active ingredients baicalin and baicalein against natural toxicities and physical hazards: a review of mechanisms.

Ahmadi A, Mortazavi Z, Mehri S, Hosseinzadeh H Daru. 2022; 30(2):351-366.

PMID: 35870110 PMC: 9715893. DOI: 10.1007/s40199-022-00443-x.

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