Extract of Protects Keratinocytes from Particulate Matter-induced Oxidative Stress

Overview

Journal Int J Med Sci

Specialty General Medicine

Date 2020 Jan 14

PMID 31929739

Citations 16

Authors

Pincha Devage Sameera Madushan Fernando

Mei Jing Piao

Ao Xuan Zhen

Mee Jung Ahn

Joo Mi Yi

Yung Hyun Choi

Jin Won Hyun

Affiliations

Soon will be listed here.

Abstract

The skin is one of the large organs in the human body and the most exposed to outdoor contaminants such as particulate matter < 2.5 µm (PM). Recently, we reported that PM induced cellular macromolecule disruption of lipids, proteins, and DNA, via reactive oxygen species, eventually causing cellular apoptosis of human keratinocytes. In this study, the ethanol extract of fruit (EECF) showed anti-oxidant effect against PM-induced cellular oxidative stress. EECF protected cells against PM-induced DNA damage, lipid peroxidation, and protein carbonylation. PM up-regulated intracellular and mitochondrial Ca levels excessively, which led to mitochondrial depolarization and cellular apoptosis. However, EECF suppressed the PM-induced excessive Ca accumulation and inhibited apoptosis. The data confirmed that EECF greatly protected human HaCaT keratinocytes from PM-induced oxidative stress.

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