Effect of Chronic Morphine Administration on Circulating Dendritic Cells in SIV-infected Rhesus Macaques

Overview

Journal J Neuroimmunol

Specialty Neurology

Date 2016 May 29

PMID 27235346

Citations 3

Authors

William D Cornwell

Wendeline Wagner

Mark G Lewis

Xiaoxuan Fan

Jay Rappaport

Thomas J Rogers

Affiliations

Soon will be listed here.

Abstract

We studied the effect of chronic morphine administration on the circulating dendritic cell population dynamics associated with SIV infection using rhesus macaques. Animals were either first infected with SIV and then given chronic morphine, or visa versa. SIV infection increased the numbers of myeloid DCs (mDCs), but morphine treatment attenuated this mDC expansion. In contrast, morphine increased the numbers of plasmacytoid DCs (pDCs) in SIV-infected animals. Finally, chronic morphine administration (no SIV) transiently increased the numbers of circulating pDCs. These results show that chronic morphine induces a significant alteration in the available circulating levels of critical antigen-presenting cells.

Citing Articles

Opioid abuse and SIV infection in non-human primates.

Deshetty U, Ray S, Singh S, Buch S, Periyasamy P J Neurovirol. 2023; 29(4):377-388.

PMID: 37418108 PMC: 10729652. DOI: 10.1007/s13365-023-01153-z.

Morphine suppresses peripheral responses and transforms brain myeloid gene expression to favor neuropathogenesis in SIV infection.

Fox H, Niu M, Morsey B, Lamberty B, Emanuel K, Periyasamy P Front Immunol. 2022; 13:1012884.

PMID: 36466814 PMC: 9709286. DOI: 10.3389/fimmu.2022.1012884.

Opioid-Mediated HIV-1 Immunopathogenesis.

Buch S, Periyasamy P, Thangaraj A, Sil S, Chivero E, Tripathi A J Neuroimmune Pharmacol. 2020; 15(4):628-642.

PMID: 33029670 PMC: 7872067. DOI: 10.1007/s11481-020-09960-5.

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