Jay Rappaport
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Explore the profile of Jay Rappaport including associated specialties, affiliations and a list of published articles.
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108
Citations
2192
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Recent Articles
1.
Kondrachuck O, Ciccone P, Ford N, Hong K, Kimura Y, Zi J, et al.
Int J Mol Sci
. 2024 Nov;
25(21.
PMID: 39518954
HIV-associated cardiovascular diseases remain a leading cause of death in people living with HIV/AIDS (PLWHA). Although antiretroviral drugs suppress the viral load, they fail to remove the virus entirely. HIV-1...
2.
Thirugnanam S, Wang C, Zheng C, Grasperge B, Datta P, Rappaport J, et al.
Int J Mol Sci
. 2024 Aug;
25(16.
PMID: 39201388
HIV-induced persistent immune activation is a key mediator of inflammatory comorbidities such as cardiovascular disease (CVD) and neurocognitive disorders. While a preponderance of data indicate that gut barrier disruption and...
3.
Palmer C, Perdios C, Abdel-Mohsen M, Mudd J, Datta P, Maness N, et al.
Nat Commun
. 2024 Aug;
15(1):6664.
PMID: 39164284
Hyperglycemia, and exacerbation of pre-existing deficits in glucose metabolism, are manifestations of the post-acute sequelae of SARS-CoV-2. Our understanding of metabolic decline after acute COVID-19 remains unclear due to the...
4.
Melton A, Rowe L, Penney T, Krzykwa C, Goff K, Scheuermann S, et al.
Viruses
. 2024 Jul;
16(7).
PMID: 39066335
The effects of immunodeficiency associated with chronic HIV infection on COVID-19 disease and viral persistence have not been directly addressed in a controlled setting. In this pilot study, we exposed...
5.
Thirugnanam S, Wang C, Zheng C, Grasperge B, Datta P, Rappaport J, et al.
bioRxiv
. 2024 Jul;
PMID: 38948748
HIV-induced persistent immune activation is a key mediator of inflammatory comorbidities such as cardiovascular disease (CVD) and neurocognitive disorders. While a preponderance of data indicate that gut barrier disruption and...
6.
Currey J, Ellsworth C, Shamima Khatun M, Wang C, Chen Z, Liu S, et al.
Biochim Biophys Acta Mol Basis Dis
. 2024 Jun;
1870(7):167322.
PMID: 38942338
Obesity is a risk factor for developing severe COVID-19. However, the mechanism underlying obesity-accelerated COVID-19 remains unclear. Here, we report results from a study in which 2-3-month-old K18-hACE2 (K18) mice...
7.
Wang C, Shamima Khatun M, Zhang Z, Allen M, Chen Z, Ellsworth C, et al.
Commun Biol
. 2023 Dec;
6(1):1265.
PMID: 38092883
SARS-CoV-2 infection can cause persistent respiratory sequelae. However, the underlying mechanisms remain unclear. Here we report that sub-lethally infected K18-human ACE2 mice show patchy pneumonia associated with histiocytic inflammation and...
8.
Melton A, Rowe L, Penney T, Krzykwa C, Goff K, Scheuermann S, et al.
bioRxiv
. 2023 Nov;
PMID: 38014096
Persistent and uncontrolled SARS-CoV-2 replication in immunocompromised individuals has been observed and may be a contributing source of novel viral variants that continue to drive the pandemic. Importantly, the effects...
9.
Li H, McLaurin K, Mactutus C, Rappaport J, Datta P, Booze R
Mol Biomed
. 2023 Nov;
4(1):39.
PMID: 37934362
No abstract available.
10.
Thirugnanam S, Walker E, Schiro F, Aye P, Rappaport J, Rout N
Viruses
. 2023 Sep;
15(9).
PMID: 37766350
Previous studies have indicated that the loss of CD161-expressing CD4 Th17 cells is linked to the progression of chronic HIV. These cells are significantly depleted in peripheral blood and gut...