Harnessing the Beneficial Heterologous Effects of Vaccination

Overview

Journal Nat Rev Immunol

Specialty Allergy & Immunology

Date 2016 May 10

PMID 27157064

Citations 133

Authors

Helen S Goodridge

S Sohail Ahmed

Nigel Curtis

Tobias R Kollmann

Ofer Levy

Mihai G Netea

Andrew J Pollard

Reinout van Crevel

Christopher B Wilson

Affiliations

Soon will be listed here.

Abstract

Clinical evidence strongly suggests that certain live vaccines, in particular bacille Calmette-Guérin (BCG) and measles vaccines, can reduce all-cause mortality, most probably through protection against non-targeted pathogens in addition to the targeted pathogen. The underlying mechanisms are currently unknown. We discuss how heterologous lymphocyte activation and innate immune memory could promote protection beyond the intended target pathogen and consider how vaccinologists could leverage heterologous immunity to improve outcomes in vulnerable populations, in particular the very young and the elderly.

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