Impact of Vaccine Platform and BCG Vaccination on Antibody Responses to COVID-19 Vaccination

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2023 Jul 19

PMID 37465688

Authors

Nicole L Messina

Mariana G Sperotto

Marco A M Puga

Patricia V da Silva

Roberto D de Oliveira

Cecilia L Moore

Laure F Pittet

Tenaya Jamieson

Margareth Dalcolmo

Glauce Dos Santos

Bruno Jardim

Marcus V G Lacerda

Nigel Curtis

Julio Croda

Affiliations

Soon will be listed here.

Abstract

Multiple factors, including vaccine platform and prior vaccinations, influence vaccine responses. We compared antibody responses to CoronaVac (Sinovac) and ChAdOx1-S (AstraZeneca-Oxford) vaccination in 874 healthcare workers in Brazil. As participants were randomised to BCG vaccination or placebo in the preceding 0-6 months as part of the BCG vaccination to reduce the impact of COVID-19 in healthcare workers (BRACE) trial, we also investigated the influence of recent BCG vaccination on antibody responses to these COVID-19 vaccines. Twenty-eight days after the second dose of each vaccine, ChAdOx1-S induced a stronger anti-spike IgG response than CoronaVac vaccination. Recent BCG vaccination did not impact IgG antibody responses to ChAdOx1-S or CoronaVac.

Citing Articles

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