Aptamer-nanoparticle Complexes As Powerful Diagnostic and Therapeutic Tools

Overview

Journal Exp Mol Med

Specialties Biochemistry
Molecular Biology

Date 2016 May 7

PMID 27151454

Citations 57

Authors

Hunho Jo

Changill Ban

Affiliations

Soon will be listed here.

Abstract

Correct diagnosis and successful therapy are extremely important to enjoy a healthy life when suffering from a disease. To achieve these aims, various cutting-edge technologies have been designed and fabricated to diagnose and treat specific diseases. Among these technologies, aptamer-nanomaterial hybrids have received considerable attention from scientists and doctors because they have numerous advantages over other methods, such as good biocompatibility, low immunogenicity and controllable selectivity. In particular, aptamers, oligonucleic acids or peptides that bind to a specific target molecule, are regarded as outstanding biomolecules. In this review, several screening techniques for aptamers, also called systematic evolution of ligands by exponential enrichment (SELEX) methods, are introduced, and diagnostic and therapeutic aptamer applications are also presented. Furthermore, we describe diverse aptamer-nanomaterial conjugate designs and their applications for diagnosis and therapy.

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References

Carothers J, Oestreich S, Szostak J . Aptamers selected for higher-affinity binding are not more specific for the target ligand. J Am Chem Soc. 2006; 128(24):7929-37. PMC: 4287982. DOI: 10.1021/ja060952q. View

Jo H, Youn H, Lee S, Ban C . Ultra-effective photothermal therapy for prostate cancer cells using dual aptamer-modified gold nanostars. J Mater Chem B. 2020; 2(30):4862-4867. DOI: 10.1039/c4tb00643g. View

Liang H, Zhang X, Lv Y, Gong L, Wang R, Zhu X . Functional DNA-containing nanomaterials: cellular applications in biosensing, imaging, and targeted therapy. Acc Chem Res. 2014; 47(6):1891-901. PMC: 4066909. DOI: 10.1021/ar500078f. View

Jelveh S, Chithrani D . Gold nanostructures as a platform for combinational therapy in future cancer therapeutics. Cancers (Basel). 2013; 3(1):1081-110. PMC: 3756404. DOI: 10.3390/cancers3011081. View

Tuerk C, Gold L . Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science. 1990; 249(4968):505-10. DOI: 10.1126/science.2200121. View

Niazi J, Lee S, Gu M . Single-stranded DNA aptamers specific for antibiotics tetracyclines. Bioorg Med Chem. 2008; 16(15):7245-53. DOI: 10.1016/j.bmc.2008.06.033. View

Min K, Jo H, Song K, Cho M, Chun Y, Jon S . Dual-aptamer-based delivery vehicle of doxorubicin to both PSMA (+) and PSMA (-) prostate cancers. Biomaterials. 2010; 32(8):2124-32. DOI: 10.1016/j.biomaterials.2010.11.035. View

Hwang K, Lee S, Eom K, Lee J, Lee Y, Park J . Nanomechanical microcantilever operated in vibration modes with use of RNA aptamer as receptor molecules for label-free detection of HCV helicase. Biosens Bioelectron. 2007; 23(4):459-65. DOI: 10.1016/j.bios.2007.05.006. View

Luo Y, Shiao Y, Huang Y . Release of photoactivatable drugs from plasmonic nanoparticles for targeted cancer therapy. ACS Nano. 2011; 5(10):7796-804. DOI: 10.1021/nn201592s. View

10.

Levesque D, Beaudoin J, Roy S, Perreault J . In vitro selection and characterization of RNA aptamers binding thyroxine hormone. Biochem J. 2006; 403(1):129-38. PMC: 1828902. DOI: 10.1042/BJ20061216. View

11.

Roncancio D, Yu H, Xu X, Wu S, Liu R, DeBord J . A label-free aptamer-fluorophore assembly for rapid and specific detection of cocaine in biofluids. Anal Chem. 2014; 86(22):11100-6. DOI: 10.1021/ac503360n. View

12.

Wang J, Zhu G, You M, Song E, Shukoor M, Zhang K . Assembly of aptamer switch probes and photosensitizer on gold nanorods for targeted photothermal and photodynamic cancer therapy. ACS Nano. 2012; 6(6):5070-7. PMC: 3407577. DOI: 10.1021/nn300694v. View

13.

Sarver M, Zirbel C, Stombaugh J, Mokdad A, Leontis N . FR3D: finding local and composite recurrent structural motifs in RNA 3D structures. J Math Biol. 2007; 56(1-2):215-52. PMC: 2837920. DOI: 10.1007/s00285-007-0110-x. View

14.

Mu C, Dave N, Hu J, Desai P, Pauletti G, Bai S . Solubilization of flurbiprofen into aptamer-modified PEG-PLA micelles for targeted delivery to brain-derived endothelial cells in vitro. J Microencapsul. 2013; 30(7):701-8. DOI: 10.3109/02652048.2013.778907. View

15.

Yang L, Zhang X, Ye M, Jiang J, Yang R, Fu T . Aptamer-conjugated nanomaterials and their applications. Adv Drug Deliv Rev. 2011; 63(14-15):1361-70. PMC: 3245877. DOI: 10.1016/j.addr.2011.10.002. View

16.

Bini A, Minunni M, Tombelli S, Centi S, Mascini M . Analytical performances of aptamer-based sensing for thrombin detection. Anal Chem. 2007; 79(7):3016-9. DOI: 10.1021/ac070096g. View

17.

Lu A, Salabas E, Schuth F . Magnetic nanoparticles: synthesis, protection, functionalization, and application. Angew Chem Int Ed Engl. 2007; 46(8):1222-44. DOI: 10.1002/anie.200602866. View

18.

Gilbert J, DeFeo-Fraulini T, Hutabarat R, Horvath C, Merlino P, Marsh H . First-in-human evaluation of anti von Willebrand factor therapeutic aptamer ARC1779 in healthy volunteers. Circulation. 2007; 116(23):2678-86. DOI: 10.1161/CIRCULATIONAHA.107.724864. View

19.

Nimjee S, Rusconi C, Sullenger B . Aptamers: an emerging class of therapeutics. Annu Rev Med. 2005; 56:555-83. DOI: 10.1146/annurev.med.56.062904.144915. View

20.

Das R, Karanicolas J, Baker D . Atomic accuracy in predicting and designing noncanonical RNA structure. Nat Methods. 2010; 7(4):291-4. PMC: 2854559. DOI: 10.1038/nmeth.1433. View