A Photothermally Responsive Nanoprobe for Bioimaging Based on Edman Degradation

Overview

Journal Nanoscale

Specialty Biotechnology

Date 2016 May 6

PMID 27149392

Citations 5

Authors

Yi Liu

Zhantong Wang

Huimin Zhang

Lixin Lang

Ying Ma

Qianjun He

Nan Lu

Peng Huang

Yijing Liu

Jibin Song

Zhibo Liu

Shi Gao

Qingjie Ma

Dale O Kiesewetter

Xiaoyuan Chen

Affiliations

Soon will be listed here.

Abstract

A new type of photothermally responsive nanoprobe based on Edman degradation has been synthesized and characterized. Under irradiation by an 808 nm laser, the heat generated by the gold nanorod core breaks the thiocarbamide structure and releases the fluorescent dye Cy5.5 with increased near-infrared (NIR) fluorescence under mild acidic conditions. This RGD modified nanoprobe is capable of fluorescence imaging of ανβ3 over-expressing U87MG cells in vitro and in vivo. This Edman degradation-based nanoprobe provides a novel strategy to design activatable probes for biomedical imaging and drug/gene delivery.

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