Wearable 3-D Photoacoustic Tomography for Functional Brain Imaging in Behaving Rats

Overview

Journal Sci Rep

Specialty Science

Date 2016 May 6

PMID 27146026

Citations 33

Authors

Jianbo Tang

Jason E Coleman

Xianjin Dai

Huabei Jiang

Affiliations

Soon will be listed here.

Abstract

Understanding the relationship between brain function and behavior remains a major challenge in neuroscience. Photoacoustic tomography (PAT) is an emerging technique that allows for noninvasive in vivo brain imaging at micrometer-millisecond spatiotemporal resolution. In this article, a novel, miniaturized 3D wearable PAT (3D-wPAT) technique is described for brain imaging in behaving rats. 3D-wPAT has three layers of fully functional acoustic transducer arrays. Phantom imaging experiments revealed that the in-plane X-Y spatial resolutions were ~200 μm for each acoustic detection layer. The functional imaging capacity of 3D-wPAT was demonstrated by mapping the cerebral oxygen saturation via multi-wavelength irradiation in behaving hyperoxic rats. In addition, we demonstrated that 3D-wPAT could be used for monitoring sensory stimulus-evoked responses in behaving rats by measuring hemodynamic responses in the primary visual cortex during visual stimulation. Together, these results show the potential of 3D-wPAT for brain study in behaving rodents.

Citing Articles

Emerging Wearable Acoustic Sensing Technologies.

Liu T, Mao Y, Dou H, Zhang W, Yang J, Wu P Adv Sci (Weinh). 2025; 12(6):e2408653.

PMID: 39749384 PMC: 11809411. DOI: 10.1002/advs.202408653.

Label-free photoacoustic computed tomography of visually evoked responses in the primary visual cortex and four subcortical retinorecipient nuclei of anesthetized mice.

Chang K, Wang X, Wong K, Xu G Neurophotonics. 2024; 11(3):035005.

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Photoacoustic microscopy for real-time monitoring of near-infrared optical absorbers inside biological tissue.

Hirasawa T, Tachi K, Ishikawa T, Miyashita M, Ito K, Ishihara M J Biomed Opt. 2024; 29(Suppl 1):S11527.

PMID: 38464883 PMC: 10924425. DOI: 10.1117/1.JBO.29.S1.S11527.

Deep learning on photoacoustic tomography to remove image distortion due to inaccurate measurement of the scanning radius.

Mondal S, Paul S, Singh N, Saha R Biomed Opt Express. 2023; 14(11):5817-5832.

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