Oxygen Saturation Imaging Using LED-Based Photoacoustic System

Overview

Journal Sensors (Basel)

Publisher MDPI

Specialty Biotechnology

Date 2021 Jan 7

PMID 33406653

Citations 21

Authors

Rianne Bulsink

Mithun Kuniyil Ajith Singh

Marvin Xavierselvan

Srivalleesha Mallidi

Wiendelt Steenbergen

Kalloor Joseph Francis

Affiliations

Soon will be listed here.

Abstract

Oxygen saturation imaging has potential in several preclinical and clinical applications. Dual-wavelength LED array-based photoacoustic oxygen saturation imaging can be an affordable solution in this case. For the translation of this technology, there is a need to improve its accuracy and validate it against ground truth methods. We propose a fluence compensated oxygen saturation imaging method, utilizing structural information from the ultrasound image, and prior knowledge of the optical properties of the tissue with a Monte-Carlo based light propagation model for the dual-wavelength LED array configuration. We then validate the proposed method with oximeter measurements in tissue-mimicking phantoms. Further, we demonstrate in vivo imaging on small animal and a human subject. We conclude that the proposed oxygen saturation imaging can be used to image tissue at a depth of 6-8 mm in both preclinical and clinical applications.

Citing Articles

Photoacoustic imaging of rat kidney tissue oxygenation using second near-infrared wavelengths.

Vincely V, Bayer C J Biomed Opt. 2025; 30(2):026002.

PMID: 39968505 PMC: 11833698. DOI: 10.1117/1.JBO.30.2.026002.

Quantitative photoacoustic imaging using known chromophores as fluence marker.

Thomas A, Rietberg M, Akkus M, van Soest G, Francis K Photoacoustics. 2025; 41():100673.

PMID: 39830068 PMC: 11741946. DOI: 10.1016/j.pacs.2024.100673.

Enhancing signal-to-noise ratio in real-time LED-based photoacoustic imaging: A comparative study of CNN-based deep learning architectures.

Paul A, Mallidi S Photoacoustics. 2025; 41:100674.

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In vivo, online label-free monitoring of heterogenous oxygen utilization during phototherapy with real-time ultrasound-guided photoacoustic imaging.

Langley A, Sweeney A, Shethia R, Bednarke B, Wulandana F, Xavierselvan M bioRxiv. 2024; .

PMID: 39677615 PMC: 11642742. DOI: 10.1101/2024.11.27.625759.

human teeth imaging with various photoacoustic imaging systems.

Periyasamy V, Gisi K, Pramanik M Biomed Opt Express. 2024; 15(9):5479-5490.

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