Biofilms and Cyclic Di-GMP (c-di-GMP) Signaling: Lessons from Pseudomonas Aeruginosa and Other Bacteria

Overview

Journal J Biol Chem

Specialty Biochemistry

Date 2016 Apr 30

PMID 27129226

Citations 260

Authors

Martina Valentini

Alain Filloux

Affiliations

Soon will be listed here.

Abstract

The cyclic di-GMP (c-di-GMP) second messenger represents a signaling system that regulates many bacterial behaviors and is of key importance for driving the lifestyle switch between motile loner cells and biofilm formers. This review provides an up-to-date compendium of c-di-GMP pathways connected to biofilm formation, biofilm-associated motilities, and other functionalities in the ubiquitous and opportunistic human pathogen Pseudomonas aeruginosa This bacterium is frequently adopted as a model organism to study bacterial biofilm formation. Importantly, its versatility and adaptation capabilities are linked with a broad range of complex regulatory networks, including a large set of genes involved in c-di-GMP biosynthesis, degradation, and transmission.

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