How Relevant is Panallergen Sensitization in the Development of Allergies?

Overview

Journal Pediatr Allergy Immunol

Specialty Pediatrics

Date 2016 Apr 30

PMID 27129102

Citations 20

Authors

Olivia E McKenna

Claudia Asam

Galber R Araujo

Anargyros Roulias

Luiz R Goulart

Fatima Ferreira

Affiliations

Soon will be listed here.

Abstract

Panallergens comprise various protein families of plant as well as animal origin and are responsible for wide IgE cross-reactivity between related and unrelated allergenic sources. Such cross-reactivities include reactions between various pollen sources, pollen and plant-derived foods as well as invertebrate-derived inhalants and foodstuff. Here, we provide an overview on the most clinically relevant panallergens from plants (profilins, polcalcins, non-specific lipid transfer proteins, pathogenesis-related protein family 10 members) and on the prominent animal-derived panallergen family, tropomyosins. In addition, we explore the role of panallergens in the sensitization process and progress of the allergic disease. Emphasis is given on epidemiological aspects of panallergen sensitization and clinical manifestations. Finally, the issues related to diagnosis and therapy of patients sensitized to panallergens are outlined, and the use of panallergens as predictors for cross-reactive allergy and as biomarkers for disease severity is discussed.

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