Prevalence and Determinants of Vitamin D Deficiency in Healthy French Adults: the VARIETE Study

Overview

Journal Endocrine

Specialty Endocrinology

Date 2016 Apr 24

PMID 27106800

Citations 32

Authors

Jean-Claude Souberbielle

Catherine Massart

Sylvie Brailly-Tabard

Etienne Cavalier

Philippe Chanson

Affiliations

Soon will be listed here.

Abstract

The U.S. Institute of Medicine considers that a serum 25-hydroxyvitamin D (25OHD) concentration >20 ng/mL corresponds to optimal vitamin D status in the general population. Old studies of vitamin D status in the French general population have demonstrated high prevalence of insufficiency. We measured serum 25OHD, 1,25(OH)2D, PTH, calcium, phosphorus, and creatinine levels in 892 French Caucasian healthy subjects (463 men, 429 women) aged from 18 to 89 years. The 25OHD concentration was similar in men (24.1 ± 8.2 ng/mL) and women (23.4 ± 8.0 ng/mL). 25OHD concentrations of <10, <12, <20, and <30 ng/mL were found in respectively 6.3, 9.9, 34.6, and 80.3 % of subjects. Residence in northern France (odds ratio [OR] 1.91), blood sampling between January and March (OR 7.74), BMI ≥24 kg/m(2) (OR 1.81), and age 60 years or more (OR 1.99) were significant determinants of hypovitaminosis D (25OHD <20 ng/mL). The serum 25OHD level correlated positively with 1,25(OH)2D and negatively with PTH. 25OHD values below 20 ng/mL were associated with lower 1,25(OH)2D levels, and 25OHD values below 27 ng/mL were associated with higher PTH levels. Many French healthy adults have a 25OHD concentration <20 ng/mL, especially during winter months. Actions to improve the vitamin D status of the French general population are urgently needed.

Citing Articles

Vitamin D deficiency in Ukraine: A multicentre cross-sectional study.

Shatylo S, Bogomaz V, Babych O Glob Epidemiol. 2024; 8:100170.

PMID: 39483738 PMC: 11525160. DOI: 10.1016/j.gloepi.2024.100170.

Prevalence and Causes of Vitamin D Deficiency in a Cohort of Greek HIV-Infected Individuals: A Prospective, Single Center, Observational Study.

Androutsakos T, Politou M, Boti S, Pittaras T, Kontos A, Kordossis T Curr HIV Res. 2024; 22(4):240-248.

PMID: 38874038 DOI: 10.2174/011570162X302844240605104855.

COVID-19 infection and metabolic comorbidities: Mitigating role of nutritional sufficiency and drug - nutraceutical combinations of vitamin D.

Mandal S, Tare M, Deepa P Hum Nutr Metab. 2024; 31:200179.

PMID: 38620788 PMC: 9762046. DOI: 10.1016/j.hnm.2022.200179.

Bone mineral density in adults with arthrogryposis multiplex congenita: a retrospective cohort analysis.

Romand X, Gastaldi R, Perennou D, Baillet A, Dieterich K Sci Rep. 2024; 14(1):8206.

PMID: 38589451 PMC: 11001861. DOI: 10.1038/s41598-024-58083-x.

Vitamin D Status in the Adult Population of Romania-Results of the European Health Examination Survey.

Brinduse L, Eclemea I, Neculau A, Cucu M Nutrients. 2024; 16(6).

PMID: 38542778 PMC: 10975605. DOI: 10.3390/nu16060867.

References

Patel P, Mughal M, Patel P, Yagnik B, Kajale N, Mandlik R . Dietary calcium intake influences the relationship between serum 25-hydroxyvitamin D3 (25OHD) concentration and parathyroid hormone (PTH) concentration. Arch Dis Child. 2015; 101(4):316-9. DOI: 10.1136/archdischild-2015-308985. View

Black L, Seamans K, Cashman K, Kiely M . An updated systematic review and meta-analysis of the efficacy of vitamin D food fortification. J Nutr. 2012; 142(6):1102-8. DOI: 10.3945/jn.112.158014. View

Stepman H, Vanderroost A, Van Uytfanghe K, Thienpont L . Candidate reference measurement procedures for serum 25-hydroxyvitamin D3 and 25-hydroxyvitamin D2 by using isotope-dilution liquid chromatography-tandem mass spectrometry. Clin Chem. 2011; 57(3):441-8. DOI: 10.1373/clinchem.2010.152553. View

Whiting S, Bonjour J, Payen F, Rousseau B . Moderate amounts of vitamin D3 in supplements are effective in raising serum 25-hydroxyvitamin D from low baseline levels in adults: a systematic review. Nutrients. 2015; 7(4):2311-23. PMC: 4425146. DOI: 10.3390/nu7042311. View

Touvier M, Deschasaux M, Montourcy M, Sutton A, Charnaux N, Kesse-Guyot E . Interpretation of plasma PTH concentrations according to 25OHD status, gender, age, weight status, and calcium intake: importance of the reference values. J Clin Endocrinol Metab. 2014; 99(4):1196-203. DOI: 10.1210/jc.2013-3349. View

Hilger J, Friedel A, Herr R, Rausch T, Roos F, Wahl D . A systematic review of vitamin D status in populations worldwide. Br J Nutr. 2013; 111(1):23-45. DOI: 10.1017/S0007114513001840. View

Aloia J, Talwar S, Pollack S, Feuerman M, Yeh J . Optimal vitamin D status and serum parathyroid hormone concentrations in African American women. Am J Clin Nutr. 2006; 84(3):602-9. PMC: 2777656. DOI: 10.1093/ajcn/84.3.602. View

Bischoff-Ferrari H, Dawson-Hughes B, Staehelin H, Orav J, Stuck A, Theiler R . Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials. BMJ. 2009; 339:b3692. PMC: 2755728. DOI: 10.1136/bmj.b3692. View

Carter G, Berry J, Gunter E, Jones G, Jones J, Makin H . Proficiency testing of 25-hydroxyvitamin D (25-OHD) assays. J Steroid Biochem Mol Biol. 2010; 121(1-2):176-9. DOI: 10.1016/j.jsbmb.2010.03.033. View

10.

Holick M, Binkley N, Bischoff-Ferrari H, Gordon C, Hanley D, Heaney R . Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011; 96(7):1911-30. DOI: 10.1210/jc.2011-0385. View

11.

van Helden J, Weiskirchen R . Experience with the first fully automated chemiluminescence immunoassay for the quantification of 1α, 25-dihydroxy-vitamin D. Clin Chem Lab Med. 2014; 53(5):761-70. DOI: 10.1515/cclm-2014-0698. View

12.

Binkley N, Krueger D, Morgan S, Wiebe D . Current status of clinical 25-hydroxyvitamin D measurement: an assessment of between-laboratory agreement. Clin Chim Acta. 2010; 411(23-24):1976-82. PMC: 3058672. DOI: 10.1016/j.cca.2010.08.018. View

13.

van Schoor N, Lips P . Worldwide vitamin D status. Best Pract Res Clin Endocrinol Metab. 2011; 25(4):671-80. DOI: 10.1016/j.beem.2011.06.007. View

14.

Sempos C, Vesper H, Phinney K, Thienpont L, Coates P . Vitamin D status as an international issue: national surveys and the problem of standardization. Scand J Clin Lab Invest Suppl. 2012; 243:32-40. DOI: 10.3109/00365513.2012.681935. View

15.

Ross A, Manson J, Abrams S, Aloia J, Brannon P, Clinton S . The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab. 2010; 96(1):53-8. PMC: 3046611. DOI: 10.1210/jc.2010-2704. View

16.

Madsen K, Rasmussen L, Andersen R, Molgaard C, Jakobsen J, Bjerrum P . Randomized controlled trial of the effects of vitamin D–fortified milk and bread on serum 25-hydroxyvitamin D concentrations in families in Denmark during winter: the VitmaD study. Am J Clin Nutr. 2013; 98(2):374-82. DOI: 10.3945/ajcn.113.059469. View

17.

Skaaby T, Nystrup Husemoen L, Thuesen B, Pisinger C, Hannemann A, Jorgensen T . Longitudinal associations between lifestyle and vitamin D: A general population study with repeated vitamin D measurements. Endocrine. 2015; 51(2):342-50. DOI: 10.1007/s12020-015-0641-7. View

18.

Carter G, Jones J, Shannon J, Williams E, Jones G, Kaufmann M . 25-Hydroxyvitamin D assays: Potential interference from other circulating vitamin D metabolites. J Steroid Biochem Mol Biol. 2016; 164:134-138. DOI: 10.1016/j.jsbmb.2015.12.018. View

19.

Cashman K, Kiely M . Tackling inadequate vitamin D intakes within the population: fortification of dairy products with vitamin D may not be enough. Endocrine. 2015; 51(1):38-46. DOI: 10.1007/s12020-015-0711-x. View

20.

Souberbielle J, Benhamou C, Cortet B, Rousiere M, Roux C, Abitbol V . [HAS report on vitamin D measurement: don't go from an extreme situation to another as extreme situation]. Presse Med. 2014; 43(1):5-8. DOI: 10.1016/j.lpm.2013.12.005. View