Targeting Neural Circuits

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 2016 Apr 23

PMID 27104976

Citations 80

Authors

Priyamvada Rajasethupathy

Emily Ferenczi

Karl Deisseroth

Affiliations

Soon will be listed here.

Abstract

Optogenetic methodology enables direct targeting of specific neural circuit elements for inhibition or excitation while spanning timescales from the acute (milliseconds) to the chronic (many days or more). Although the impact of this temporal versatility and cellular specificity has been greater for basic science than clinical research, it is natural to ask whether the dynamic patterns of neural circuit activity discovered to be causal in adaptive or maladaptive behaviors could become targets for treatment of neuropsychiatric diseases. Here, we consider the landscape of ideas related to therapeutic targeting of circuit dynamics. Specifically, we highlight optical, ultrasonic, and magnetic concepts for the targeted control of neural activity, preclinical/clinical discovery opportunities, and recently reported optogenetically guided clinical outcomes.

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