CpG Oligodeoxynucleotides Downregulate Placental Adiponectin and Increase Embryo Loss in Non-Obese Diabetic Mice

Overview

Journal Am J Reprod Immunol

Specialties Allergy & Immunology
Reproductive Medicine

Date 2016 Apr 21

PMID 27094728

Citations 3

Authors

Chuan-Mei Qin

Fu-Ju Tian

Xiao-Rui Liu

Fan Wu

Xiao-Ling Ma

Yi Lin

Affiliations

Soon will be listed here.

Abstract

Problem: CpG oligodeoxynucleotides (ODNs) can induce immunological changes in non-obese diabetic (NOD) mice and increase embryo loss, but little is known about the mechanism. This study aimed to determine the role of adiponectin in CpG ODN-induced pregnancy failure.

Method Of Study: Oligodeoxynucleotide 1826 was intraperitoneally injected to NOD mice, and ODN 2216, ODN 2006, and ODN 2395 were used to stimulate human trophoblast cell lines to investigate adiponectin expression patterns and its possible effects on trophoblast function.

Results: CpG ODNs downregulated adiponectin via the cJun N-terminal kinase signaling pathway and led to increased embryo loss (from 6.9 to 33.3%). ODN 2006 impaired human trophoblast cell migration, which was successfully rescued by adiponectin treatment.

Conclusion: CpG ODNs decreased placental adiponectin expression in NOD mice and impaired human trophoblast function and was associated with increased embryo loss. Adiponectin may therefore play an important protective role in the prevention of bacteria-induced pregnancy failure.

Citing Articles

Role of peroxiredoxin2 downregulation in recurrent miscarriage through regulation of trophoblast proliferation and apoptosis.

Wu F, Tian F, Zeng W, Liu X, Fan J, Lin Y Cell Death Dis. 2017; 8(6):e2908.

PMID: 28661480 PMC: 5520946. DOI: 10.1038/cddis.2017.301.

Effect of the p53-tristetraprolin-stathmin-1 pathway on trophoblasts at maternal-fetal interface.

Ma X, Li X, Tian F, Zhang S, Liu X, Zhang Y PLoS One. 2017; 12(6):e0179852.

PMID: 28658321 PMC: 5489185. DOI: 10.1371/journal.pone.0179852.

CpG Oligodeoxynucleotides Downregulate Placental Adiponectin and Increase Embryo Loss in Non-Obese Diabetic Mice.

Qin C, Tian F, Liu X, Wu F, Ma X, Lin Y Am J Reprod Immunol. 2016; 76(1):38-49.

PMID: 27094728 PMC: 5074278. DOI: 10.1111/aji.12515.

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