Adiponectin As a Target in Obesity-related Inflammatory State

Overview

Journal Endocr Metab Immune Disord Drug Targets

Publisher Bentham Science Publishers

Specialties Allergy & Immunology
Endocrinology
Infectious Diseases
Pharmacology

Date 2015 Mar 17

PMID 25772181

Citations 18

Authors

Koji Ohashi

Daisuke Yuasa

Rei Shibata

Toyoaki Murohara

Noriyuki Ouchi

Affiliations

Soon will be listed here.

Abstract

Accumulating evidence indicates that low grade inflammation is closely associated with obesity-related disorders including type 2 diabetes, hypertension and atherosclerosis. Adiponectin is a fat-derived plasma protein with anti-inflammatory functions. Circulating levels of adiponectin are decreased in obese states, and these conditions are broadly associated with various obesity-related diseases. Furthermore, adiponectin has direct protective functions against cardiovascular disease, cerebrovascular disease, non-alcoholic steatohepatitis (NASH) and chronic kidney disease (CKD). In this review, we will focus on the protective functions of adiponectin against these obesity-related diseases from the view point of its anti-inflammatory properties.

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