Marrow Adipose Tissue: Trimming the Fat

Overview

Journal Trends Endocrinol Metab

Specialty Endocrinology

Date 2016 Apr 21

PMID 27094502

Citations 112

Authors

Erica L Scheller

William P Cawthorn

Aaron A Burr

Mark C Horowitz

Ormond A MacDougald

Affiliations

Soon will be listed here.

Abstract

Marrow adipose tissue (MAT) is a unique fat depot, located in the skeleton, that has the potential to contribute to both local and systemic metabolic processes. In this review we highlight several recent conceptual developments pertaining to the origin and function of MAT adipocytes; consider the relationship of MAT to beige, brown, and white adipose depots; explore MAT expansion and turnover in humans and rodents; and discuss future directions for MAT research in the context of endocrine function and metabolic disease. MAT has the potential to exert both local and systemic effects on metabolic homeostasis, skeletal remodeling, hematopoiesis, and the development of bone metastases. The diversity of these functions highlights the breadth of the potential impact of MAT on health and disease.

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