Long Non-Coding RNA-ROR Mediates the Reprogramming in Cardiac Hypertrophy

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2016 Apr 16

PMID 27082978

Citations 59

Authors

Feng Jiang

Xiangyu Zhou

Jing Huang

Affiliations

Soon will be listed here.

Abstract

Background: Cardiac hypertrophy associated with various cardiovascular diseases results in heart failure and sudden death. A clear understanding of the mechanisms of hypertrophy will benefit the development of novel therapies. Long non-coding RNAs (lncRNAs) have been shown to play essential roles in many biological process, however, whether lncRNA-ROR plays functional roles in the reprogramming of cardiomyocyte remains unclear.

Methodology/principal Findings: Here we show that lncRNA-ROR plays important roles in the pathogenesis of cardiac hypertrophy. In hypertrophic heart and cardiomyocytes, the expression of lncRNA-ROR is dramatically increased, downregulation of which attenuates the hypertrophic responses. Furthermore, the expression of lncRNA-ROR negatively correlates with miR-133, whose expression is increased when lncRNA-ROR is knocked down. In line with this, overexpression of miR-133 prevents the elevation of lncRNA-ROR and re-expression of ANP and BNP in cardiomyocytes subject to phenylephrine treatment.

Conclusions/significance: Taken together, our study demonstrates that lncRNA-ROR promotes cardiac hypertrophy via interacting with miR-133, indicating that lncRNA-ROR could be targeted for developing novel antihypertrophic therapeutics.

Citing Articles

Long Non-Coding RNAs in Cardiac Hypertrophy.

Mangraviti N, De Windt L Front Mol Med. 2024; 2:836418.

PMID: 39086960 PMC: 11285587. DOI: 10.3389/fmmed.2022.836418.

Transcriptomics data integration and analysis to uncover hallmark genes in hypertrophic cardiomyopathy.

Chen P, Yawar W, Farooqui A, Ali S, Lathiya N, Ghous Z Am J Transl Res. 2024; 16(2):637-653.

PMID: 38463581 PMC: 10918138.

Dysfunctional network of hub genes in hypertrophic cardiomyopathy patients.

Wu S, Ud Din I, Sadiq F, Abdel-Maksoud M, Haris M, Mubarak A Am J Transl Res. 2023; 14(12):8918-8933.

PMID: 36628247 PMC: 9827312.

Comparative Analysis of Non-Coding RNA Transcriptomics in Heart Failure.

Garcia-Padilla C, Lozano-Velasco E, Garcia-Lopez V, Aranega A, Franco D, Garcia-Martinez V Biomedicines. 2022; 10(12).

PMID: 36551832 PMC: 9775550. DOI: 10.3390/biomedicines10123076.

LncRNA Gm43843 Promotes Cardiac Hypertrophy via miR-153-3p/Cacna1c Axis.

Cai Y, Li Y Evid Based Complement Alternat Med. 2022; 2022:2160804.

PMID: 36262165 PMC: 9576395. DOI: 10.1155/2022/2160804.

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