High-throughput Sequencing of Immune Repertoires in Multiple Sclerosis

Overview

Journal Ann Clin Transl Neurol

Specialty Neurology

Date 2016 Apr 16

PMID 27081660

Citations 6

Authors

Andreas Lossius

Jorunn N Johansen

Frode Vartdal

Trygve Holmoy

Affiliations

Soon will be listed here.

Abstract

T cells and B cells are crucial in the initiation and maintenance of multiple sclerosis (MS), and the activation of these cells is believed to be mediated through specific recognition of antigens by the T- and B-cell receptors. The antigen receptors are highly polymorphic due to recombination (T- and B-cell receptors) and mutation (B-cell receptors) of the encoding genes, which can therefore be used as fingerprints to track individual T- and B-cell clones. Such studies can shed light on mechanisms driving the immune responses and provide new insights into the pathogenesis. Here, we summarize studies that have explored the T- and B-cell receptor repertoires using earlier methodological approaches, and we focus on how high-throughput sequencing has provided new knowledge by surveying the immune repertoires in MS in even greater detail and with unprecedented depth.

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