Brief Report: APOL1 Renal Risk Variants Are Associated With Chronic Kidney Disease in Children and Youth With Perinatal HIV Infection

Overview

Journal J Acquir Immune Defic Syndr

Specialty Infectious Diseases

Date 2016 Apr 2

PMID 27035887

Citations 19

Authors

Murli U Purswani

Kunjal Patel

Cheryl A Winkler

Stephen A Spector

Rohan Hazra

George R Seage 3rd

Lynne Mofenson

Brad Karalius

Gwendolyn B Scott

Russell B Van Dyke

Jeffrey B Kopp

Affiliations

Soon will be listed here.

Abstract

APOL1 renal risk alleles are associated with chronic kidney disease (CKD) in adults, with the strongest effect being for HIV-associated nephropathy. Their role in youth with perinatal HIV-1 infection (PHIV) has not been studied. In a nested case-control study of 451 PHIV participants in the Pediatric HIV/AIDS Cohort Study, we found a 3.5-fold increased odds of CKD in those carrying high-risk APOL1 genotypes using a recessive model [95% confidence interval (CI): 1.2 to 10.0]. We report an unadjusted incidence of 1.2 CKD cases/100 person-years (95% CI: 0.5 to 2.5) in PHIV youth carrying APOL1 high-risk genotypes, with important implications for sub-Saharan Africa.

Citing Articles

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