Stephen A Spector
Overview
Explore the profile of Stephen A Spector including associated specialties, affiliations and a list of published articles.
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175
Citations
15734
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Recent Articles
1.
Ament S, Campbell R, Lobo M, Receveur J, Agrawal K, Borjabad A, et al.
Mol Psychiatry
. 2024 Jun;
29(12):3950-3961.
PMID: 38879719
Substance use disorders (SUD) and drug addiction are major threats to public health, impacting not only the millions of individuals struggling with SUD, but also surrounding families and communities. One...
2.
Wagner T, Tierney C, Huang S, Nichols S, Malee K, Montanez N, et al.
AIDS
. 2024 May;
38(10):1494-1504.
PMID: 38814693
Objective: Central nervous system (CNS) HIV infection can impact cognition and may be an obstacle to cure in adolescents and young adults with perinatal HIV (AYAPHIV). IMPAACT2015 enrolled AYAPHIV on...
3.
Spector S, Brummel S, Chang A, Wiznia A, Ruel T, Acosta E
J Acquir Immune Defic Syndr
. 2024 Jan;
95(3):297-303.
PMID: 38180896
Background: Dolutegravir plasma concentrations and pharmacokinetic (PK) parameters in children display considerable variability. Here, the impact of genetic variants in ABCG2 421C>A (rs2231142), NR1I2 63396 C>T (rs2472677), and UGT1A1 (rs5839491)...
4.
Persaud D, Bryson Y, Nelson B, Tierney C, Cotton M, Coletti A, et al.
Lancet HIV
. 2023 Dec;
11(1):e20-e30.
PMID: 38061376
Background: Infants born with HIV-1 require lifelong antiretroviral therapy (ART). We aimed to assess whether very early ART in neonates might restrict HIV-1 reservoirs, an important step towards ART-free remission....
5.
Tencer A, Yu Y, Causse S, Campbell G, Klein B, Xuan H, et al.
Nat Struct Mol Biol
. 2023 Jul;
30(9):1265-1274.
PMID: 37524969
The inhibitor of apoptosis protein BIRC2 regulates fundamental cell death and survival signaling pathways. Here we show that BIRC2 accumulates in the nucleus via binding of its second and third...
6.
Campbell G, Rawat P, To R, Spector S
J Immunol
. 2023 Jun;
211(3):429-442.
PMID: 37326481
Because microglia are a reservoir for HIV and are resistant to the cytopathic effects of HIV infection, they are a roadblock for any HIV cure strategy. We have previously identified...
7.
Campbell G, Rawat P, Teodorof-Diedrich C, Spector S
J Gen Virol
. 2023 May;
104(5).
PMID: 37256770
Human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND) are a common source of morbidity in people living with HIV (PLWH). Although antiretroviral therapy (ART) has lessened the severity of neurocognitive disorders,...
8.
Benkeser D, Montefiori D, McDermott A, Fong Y, Janes H, Deng W, et al.
Sci Transl Med
. 2023 Apr;
15(692):eade9078.
PMID: 37075127
The best assay or marker to define mRNA-1273 vaccine-induced antibodies as a correlate of protection (CoP) is unclear. In the COVE trial, participants received two doses of the mRNA-1273 COVID-19...
9.
Adams J, Negraes P, Truong J, Tran T, Szeto R, Guerra B, et al.
Mol Psychiatry
. 2022 Nov;
28(4):1571-1584.
PMID: 36385168
Prenatal alcohol exposure is the foremost preventable etiology of intellectual disability and leads to a collection of diagnoses known as Fetal Alcohol Spectrum Disorders (FASD). Alcohol (EtOH) impacts diverse neural...
10.
Hastie E, Stangl L, Deutsch K, Yin J, Hull A, Spector S, et al.
Open Forum Infect Dis
. 2022 Aug;
9(8):ofac402.
PMID: 36043182
We describe a case of a pregnant cisgender woman diagnosed with human immunodeficiency virus (HIV)-1 using the current Centers for Disease Control and Prevention diagnostic algorithm who subsequently had her...