A Review of Ribonuclease 7's Structure, Regulation, and Contributions to Host Defense

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2016 Mar 25

PMID 27011175

Citations 28

Authors

Brian Becknell

John David Spencer

Affiliations

Soon will be listed here.

Abstract

The Ribonuclease A Superfamily is composed of a group of structurally similar peptides that are secreted by immune cells and epithelial tissues. Several members of the Ribonuclease A Superfamily demonstrate antimicrobial activity, and it has been suggested that some of these ribonucleases play an essential role in host defense. Ribonuclease 7 (RNase 7) is an epithelial-derived secreted peptide with potent broad-spectrum antimicrobial activity. This review summarizes the published literature on RNase 7's antimicrobial properties, structure, regulation, and contributions to host defense. In doing so, we conclude by highlighting key knowledge gaps that must be investigated to completely understand the potential of developing RNase 7 as a novel therapeutic for human infectious diseases.

Citing Articles

Peptidomimetic Oligomers Targeting Membrane Phosphatidylserine Exhibit Broad Antiviral Activity.

Tate P, Mastrodomenico V, Cunha C, McClure J, Barron A, Diamond G ACS Infect Dis. 2023; 9(8):1508-1522.

PMID: 37530426 PMC: 10425984. DOI: 10.1021/acsinfecdis.3c00063.

Antimicrobial skin peptides in premature infants: Comparison with term infants and impact of perinatal factors.

Humberg A, Neuenburg L, Boeckel H, Fortmann M, Hartel C, Herting E Front Immunol. 2023; 14:1093340.

PMID: 36923410 PMC: 10009099. DOI: 10.3389/fimmu.2023.1093340.

Repurposing HDAC inhibitors to enhance ribonuclease 4 and 7 expression and reduce urinary tract infection.

Schwartz L, Bochter M, Simoni A, Bender K, de Dios Ruiz Rosado J, Cotzomi-Ortega I Proc Natl Acad Sci U S A. 2023; 120(4):e2213363120.

PMID: 36652479 PMC: 9942862. DOI: 10.1073/pnas.2213363120.

Bacterial extracellular vesicles and their novel therapeutic applications in health and cancer.

Hosseini-Giv N, Basas A, Hicks C, El-Omar E, El-Assaad F, Hosseini-Beheshti E Front Cell Infect Microbiol. 2022; 12:962216.

PMID: 36439225 PMC: 9691856. DOI: 10.3389/fcimb.2022.962216.

The role of human ribonuclease A family in health and diseases: A systematic review.

Sun D, Han C, Sheng J iScience. 2022; 25(11):105284.

PMID: 36304117 PMC: 9593802. DOI: 10.1016/j.isci.2022.105284.

References

Harder J, Schroder J . RNase 7, a novel innate immune defense antimicrobial protein of healthy human skin. J Biol Chem. 2002; 277(48):46779-84. DOI: 10.1074/jbc.M207587200. View

Sorrentino S . The eight human "canonical" ribonucleases: molecular diversity, catalytic properties, and special biological actions of the enzyme proteins. FEBS Lett. 2010; 584(11):2194-200. DOI: 10.1016/j.febslet.2010.04.018. View

Spencer J, Schwaderer A, Eichler T, Wang H, Kline J, Justice S . An endogenous ribonuclease inhibitor regulates the antimicrobial activity of ribonuclease 7 in the human urinary tract. Kidney Int. 2013; 85(5):1179-91. PMC: 3981961. DOI: 10.1038/ki.2013.395. View

Spencer J, Schwaderer A, Wang H, Bartz J, Kline J, Eichler T . Ribonuclease 7, an antimicrobial peptide upregulated during infection, contributes to microbial defense of the human urinary tract. Kidney Int. 2013; 83(4):615-25. PMC: 3612368. DOI: 10.1038/ki.2012.410. View

Mun J, Tam C, Chan G, Kim J, Evans D, Fleiszig S . MicroRNA-762 is upregulated in human corneal epithelial cells in response to tear fluid and Pseudomonas aeruginosa antigens and negatively regulates the expression of host defense genes encoding RNase7 and ST2. PLoS One. 2013; 8(2):e57850. PMC: 3585208. DOI: 10.1371/journal.pone.0057850. View

Kelley L, Sternberg M . Protein structure prediction on the Web: a case study using the Phyre server. Nat Protoc. 2009; 4(3):363-71. DOI: 10.1038/nprot.2009.2. View

Rosenberg H . RNase A ribonucleases and host defense: an evolving story. J Leukoc Biol. 2008; 83(5):1079-87. PMC: 2692241. DOI: 10.1189/jlb.1107725. View

Becknell B, Schwaderer A, Hains D, Spencer J . Amplifying renal immunity: the role of antimicrobial peptides in pyelonephritis. Nat Rev Nephrol. 2015; 11(11):642-55. DOI: 10.1038/nrneph.2015.105. View

Dickson K, Haigis M, Raines R . Ribonuclease inhibitor: structure and function. Prog Nucleic Acid Res Mol Biol. 2005; 80:349-74. PMC: 2811166. DOI: 10.1016/S0079-6603(05)80009-1. View

10.

Boix E, Nogues M . Mammalian antimicrobial proteins and peptides: overview on the RNase A superfamily members involved in innate host defence. Mol Biosyst. 2007; 3(5):317-35. DOI: 10.1039/b617527a. View

11.

Simanski M, Dressel S, Glaser R, Harder J . RNase 7 protects healthy skin from Staphylococcus aureus colonization. J Invest Dermatol. 2010; 130(12):2836-8. DOI: 10.1038/jid.2010.217. View

12.

Huang Y, Lin Y, Chang T, Wu S, Lee Y, Chang M . The flexible and clustered lysine residues of human ribonuclease 7 are critical for membrane permeability and antimicrobial activity. J Biol Chem. 2006; 282(7):4626-4633. DOI: 10.1074/jbc.M607321200. View

13.

Ganz T . The role of antimicrobial peptides in innate immunity. Integr Comp Biol. 2011; 43(2):300-4. DOI: 10.1093/icb/43.2.300. View

14.

Brasch J, Morig A, Neumann B, Proksch E . Expression of antimicrobial peptides and toll-like receptors is increased in tinea and pityriasis versicolor. Mycoses. 2013; 57(3):147-52. DOI: 10.1111/myc.12118. View

15.

Zasloff M . The antibacterial shield of the human urinary tract. Kidney Int. 2013; 83(4):548-50. DOI: 10.1038/ki.2012.467. View

16.

Chassin C, Goujon J, Darche S, du Merle L, Bens M, Cluzeaud F . Renal collecting duct epithelial cells react to pyelonephritis-associated Escherichia coli by activating distinct TLR4-dependent and -independent inflammatory pathways. J Immunol. 2006; 177(7):4773-84. DOI: 10.4049/jimmunol.177.7.4773. View

17.

Chang T, Lin Y, Wang C, Liao Y . Outer membrane lipoprotein Lpp is Gram-negative bacterial cell surface receptor for cationic antimicrobial peptides. J Biol Chem. 2011; 287(1):418-428. PMC: 3249093. DOI: 10.1074/jbc.M111.290361. View

18.

Wanke I, Steffen H, Christ C, Krismer B, Gotz F, Peschel A . Skin commensals amplify the innate immune response to pathogens by activation of distinct signaling pathways. J Invest Dermatol. 2010; 131(2):382-90. DOI: 10.1038/jid.2010.328. View

19.

Boix E, Torrent M, Sanchez D, Nogues M . The antipathogen activities of eosinophil cationic protein. Curr Pharm Biotechnol. 2008; 9(3):141-52. DOI: 10.2174/138920108784567353. View

20.

Becknell B, Eichler T, Beceiro S, Li B, Easterling R, Carpenter A . Ribonucleases 6 and 7 have antimicrobial function in the human and murine urinary tract. Kidney Int. 2014; 87(1):151-61. PMC: 4281292. DOI: 10.1038/ki.2014.268. View