Engrailed-2 Might Play an Anti-oncogenic Role in Clear-cell Renal Cell Carcinoma

Overview

Journal J Mol Histol

Specialty Biochemistry

Date 2016 Mar 8

PMID 26948025

Citations 7

Authors

Cai-Yong Lai

Yin Xu

Gan-Shen Yu

Xun Wu

Yun-Fei Li

Bin Pan

Bao-Li Heng

Yi-Jun Xue

Ze-Xuan Su

Affiliations

Soon will be listed here.

Abstract

Our preliminary study indicated that Engrailed-2 (EN2) is downregulated but also ectopically expressed in clear-cell renal cell carcinoma (CCRCC), and the absence of EN2 expression was associated with poor histological grade. However, the specific roles of EN2 in CCRCC have yet to be elucidated. In the present study, we examined the effects of inhibiting EN2 expression by human renal tubular epithelial cells (HK-2) and overexpressing EN2 by human clear-cell renal cells (786-O). Results showed that EN2 inhibition accelerated HK-2 cell proliferation, shortened the cell cycle, reduced apoptosis, and acted more invasively. By contrast, EN2 overexpression in 786-O cells decelerated the proliferative ability of 786-O, increased the percentage of cell apoptosis, and weakened the invasive ability. Overall, the results demonstrated that EN2 might play an anti-oncogenic role in oncogenesis and development of CCRCC, thereby maintaining the normal growth of human renal tubular epithelial cells.

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