Nonadherence in the Advanced Heart Failure Population

Overview

Journal Curr Heart Fail Rep

Publisher Current Science

Date 2016 Feb 17

PMID 26879391

Citations 4

Authors

Jonathan Gandhi

Andrew McCue

Robert Cole

Affiliations

Soon will be listed here.

Abstract

The number of patients living with heart failure (HF) in the USA now exceeds 5 million. Although HF is a disease readily treated by medications and lifestyle interventions, nonadherence is common, leading to worse clinical outcomes and increased healthcare costs. While adherence to medical therapy and clinician recommendations is key in the management of HF, it is perhaps more critical in patients with the most advanced disease, including those receiving home inotropic infusion, heart transplantation, or a left ventricular assist device. Yet, there is a paucity of data on the effects of nonadherence on the advanced heart failure population and little information on the most effective management strategies in these patients. Future studies of nonadherence in HF should utilize uniform definitions of adherence and, ideally, more objective measurements of adherence such as the novel "digital pill" technology.

Citing Articles

Self-Care and Compliance with Medication and Their Relationship to the Quality of Life of Patients with Heart Failure.

Maria M, Panagiota K, Vasileios T, Iokasti P, Tsioumanis G, Nikolaos T Adv Exp Med Biol. 2023; 1425:417-427.

PMID: 37581815 DOI: 10.1007/978-3-031-31986-0_40.

Designing and Testing a Treatment Adherence Model Based on the Roy Adaptation Model in Patients With Heart Failure: Protocol for a Mixed Methods Study.

Shariatpanahi S, Ashghali Farahani M, Rafii F, Rassouli M, Kavousi A JMIR Res Protoc. 2019; 8(7):e13317.

PMID: 31350842 PMC: 6688435. DOI: 10.2196/13317.

Performance Improvement to Decrease Readmission Rates for Patients With a Left Ventricular Assist Device.

Iseler J, Fox J, Wierenga K Prog Transplant. 2018; 28(2):184-188.

PMID: 29558876 PMC: 5999042. DOI: 10.1177/1526924818765820.

Role of the Pharmacist for Improving Self-care and Outcomes in Heart Failure.

Parajuli D, Franzon J, McKinnon R, Shakib S, Clark R Curr Heart Fail Rep. 2017; 14(2):78-86.

PMID: 28233258 DOI: 10.1007/s11897-017-0323-2.

References

Aaronson K, Slaughter M, Miller L, McGee E, Cotts W, Acker M . Use of an intrapericardial, continuous-flow, centrifugal pump in patients awaiting heart transplantation. Circulation. 2012; 125(25):3191-200. DOI: 10.1161/CIRCULATIONAHA.111.058412. View

Kirklin J, Naftel D, Kormos R, Stevenson L, Pagani F, Miller M . Fifth INTERMACS annual report: risk factor analysis from more than 6,000 mechanical circulatory support patients. J Heart Lung Transplant. 2013; 32(2):141-56. DOI: 10.1016/j.healun.2012.12.004. View

Marti C, Georgiopoulou V, Giamouzis G, Cole R, Deka A, Tang W . Patient-reported selective adherence to heart failure self-care recommendations: a prospective cohort study: the Atlanta Cardiomyopathy Consortium. Congest Heart Fail. 2012; 19(1):16-24. PMC: 3519965. DOI: 10.1111/j.1751-7133.2012.00308.x. View

Kato N, Jaarsma T, Ben Gal T . Learning self-care after left ventricular assist device implantation. Curr Heart Fail Rep. 2014; 11(3):290-8. DOI: 10.1007/s11897-014-0201-0. View

Ben Gal T, Jaarsma T . Self-care and communication issues at the end of life of recipients of a left-ventricular assist device as destination therapy. Curr Opin Support Palliat Care. 2013; 7(1):29-35. DOI: 10.1097/SPC.0b013e32835d2d50. View

Slaughter M, Rogers J, Milano C, Russell S, Conte J, Feldman D . Advanced heart failure treated with continuous-flow left ventricular assist device. N Engl J Med. 2009; 361(23):2241-51. DOI: 10.1056/NEJMoa0909938. View

Miller L, Pagani F, Russell S, John R, Boyle A, Aaronson K . Use of a continuous-flow device in patients awaiting heart transplantation. N Engl J Med. 2007; 357(9):885-96. DOI: 10.1056/NEJMoa067758. View

Wong C, Chaudhry S, Desai M, Krumholz H . Trends in comorbidity, disability, and polypharmacy in heart failure. Am J Med. 2011; 124(2):136-43. PMC: 3237399. DOI: 10.1016/j.amjmed.2010.08.017. View

Palardy L, March A . The circle of caring model: medication adherence in cardiac transplant patients. Nurs Sci Q. 2011; 24(2):120-5. DOI: 10.1177/0894318411399463. View

10.

Christensen M, Lundh A . Medication review in hospitalised patients to reduce morbidity and mortality. Cochrane Database Syst Rev. 2013; (2):CD008986. DOI: 10.1002/14651858.CD008986.pub2. View

11.

Blanca Martinez Perez A, Suarez A, Rodriguez Rodriguez J, Sobrino Marquez J, Lage Galle E . Medication adherence in patients who undergo cardiac transplantation. Transplant Proc. 2013; 45(10):3662-4. DOI: 10.1016/j.transproceed.2013.11.006. View

12.

De Bleser L, Dobbels F, Berben L, Vanhaecke J, Verleden G, Nevens F . The spectrum of nonadherence with medication in heart, liver, and lung transplant patients assessed in various ways. Transpl Int. 2011; 24(9):882-91. DOI: 10.1111/j.1432-2277.2011.01296.x. View

13.

Osterberg L, Blaschke T . Adherence to medication. N Engl J Med. 2005; 353(5):487-97. DOI: 10.1056/NEJMra050100. View

14.

Roger V, Go A, Lloyd-Jones D, Benjamin E, Berry J, Borden W . Heart disease and stroke statistics--2012 update: a report from the American Heart Association. Circulation. 2011; 125(1):e2-e220. PMC: 4440543. DOI: 10.1161/CIR.0b013e31823ac046. View

15.

Au-Yeung K, Moon G, Robertson T, DiCarlo L, Epstein M, Weis S . Early clinical experience with networked system for promoting patient self-management. Am J Manag Care. 2011; 17(7):e277-87. View

16.

Stevenson L . Projecting heart failure into bankruptcy in 2012?. Am Heart J. 2011; 161(6):1007-11. DOI: 10.1016/j.ahj.2011.03.020. View

17.

Fitzgerald A, Powers J, Ho P, Maddox T, Peterson P, Allen L . Impact of medication nonadherence on hospitalizations and mortality in heart failure. J Card Fail. 2011; 17(8):664-9. DOI: 10.1016/j.cardfail.2011.04.011. View

18.

Dew M, Kormos R, Roth L, Murali S, DiMartini A, Griffith B . Early post-transplant medical compliance and mental health predict physical morbidity and mortality one to three years after heart transplantation. J Heart Lung Transplant. 1999; 18(6):549-62. DOI: 10.1016/s1053-2498(98)00044-8. View

19.

Eisenberger U, Wuthrich R, Bock A, Ambuhl P, Steiger J, Intondi A . Medication adherence assessment: high accuracy of the new Ingestible Sensor System in kidney transplants. Transplantation. 2013; 96(3):245-50. PMC: 3749815. DOI: 10.1097/TP.0b013e31829b7571. View

20.

Lindenfeld J, Miller G, Shakar S, Zolty R, Lowes B, Wolfel E . Drug therapy in the heart transplant recipient: part I: cardiac rejection and immunosuppressive drugs. Circulation. 2004; 110(24):3734-40. DOI: 10.1161/01.CIR.0000149745.83186.89. View