Competing Endogenous RNA Networks in Human Cancer: Hypothesis, Validation, and Perspectives

Overview

Journal Oncotarget

Specialty Oncology

Date 2016 Feb 13

PMID 26872371

Citations 111

Authors

Chao Yang

Di Wu

Lin Gao

Xi Liu

Yinji Jin

Dong Wang

Tianzhen Wang

Xiaobo Li

Affiliations

Soon will be listed here.

Abstract

Non-coding RNAs represent a majority of the human transcriptome. However, less is known about the functions and regulatory mechanisms of most non-coding species. Moreover, little is known about the potential non-coding functions of coding RNAs. The competing endogenous RNAs (ceRNAs) hypothesis is proposed recently. This hypothesis describes potential communication networks among all transcript RNA species mediated by miRNAs and miRNA-recognizing elements (MREs) within RNA transcripts. Here we review the evolution of the ceRNA hypothesis, summarize the validation experiments and discusses the significance and perspectives of this hypothesis in human cancer.

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