New Mechanism of LncRNA: In Addition to Act As a CeRNA

Overview

Journal Noncoding RNA Res

Date 2024 Jul 18

PMID 39022688

Authors

Jiahao Zhang

Huike Zhu

Linjing Li

Yuting Gao

Boyi Yu

Guorong Ma

Xiaodong Jin

Yingbiao Sun

Affiliations

Soon will be listed here.

Abstract

Long non-coding RNAs (LncRNAs) are a class of RNA molecules with nucleic acid lengths ranging from 200 bp to 100 kb that cannot code for proteins, which are diverse and widely expressed in both animals and plants. Scholars have found that lncRNAs can regulate human physiological processes at the gene and protein levels, mainly through the regulation of epigenetic, transcriptional and post-transcriptional levels of genes and proteins, as well as in the immune response by regulating the expression of immune cells and inflammatory factors, and thus participate in the occurrence and development of a variety of diseases. From the downstream targets of lncRNAs, we summarize the new research progress of lncRNA mechanisms other than miRNA sponges in recent years, aiming to provide new ideas and directions for the study of lncRNA mechanisms.

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References

Ding H, Wang F, Shi X, Ma H, Du Y, Hou L . LncRNA MALAT1 induces the dysfunction of β cells via reducing the histone acetylation of the PDX-1 promoter in type 1 diabetes. Exp Mol Pathol. 2020; 114:104432. DOI: 10.1016/j.yexmp.2020.104432. View

Anastasiadi D, Esteve-Codina A, Piferrer F . Consistent inverse correlation between DNA methylation of the first intron and gene expression across tissues and species. Epigenetics Chromatin. 2018; 11(1):37. PMC: 6025724. DOI: 10.1186/s13072-018-0205-1. View

Cesana M, Cacchiarelli D, Legnini I, Santini T, Sthandier O, Chinappi M . A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA. Cell. 2011; 147(2):358-69. PMC: 3234495. DOI: 10.1016/j.cell.2011.09.028. View

Carrieri C, Cimatti L, Biagioli M, Beugnet A, Zucchelli S, Fedele S . Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat. Nature. 2012; 491(7424):454-7. DOI: 10.1038/nature11508. View

Ji X, Liu Z, Gao J, Bing X, He D, Liu W . N-Methyladenosine-modified lncRNA LINREP promotes Glioblastoma progression by recruiting the PTBP1/HuR complex. Cell Death Differ. 2022; 30(1):54-68. PMC: 9883516. DOI: 10.1038/s41418-022-01045-5. View

Davies C, Godwin J, Gray R, Clarke M, Cutter D, Darby S . Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials. Lancet. 2011; 378(9793):771-84. PMC: 3163848. DOI: 10.1016/S0140-6736(11)60993-8. View

Diallo I, Seve M, Cunin V, Minassian F, Poisson J, Michelland S . Current trends in protein acetylation analysis. Expert Rev Proteomics. 2018; 16(2):139-159. DOI: 10.1080/14789450.2019.1559061. View

Gao Z, Xu J, Fan Y, Qi Y, Wang S, Zhao S . PDIA3P1 promotes Temozolomide resistance in glioblastoma by inhibiting C/EBPβ degradation to facilitate proneural-to-mesenchymal transition. J Exp Clin Cancer Res. 2022; 41(1):223. PMC: 9284800. DOI: 10.1186/s13046-022-02431-0. View

Wang Y, Zhang Y, Lin Z, Zhang H, Wang T, Cao Y . Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups. Nat Commun. 2021; 12(1):772. PMC: 7858632. DOI: 10.1038/s41467-021-21049-y. View

10.

Huang J, Chen M, Chen D, Gao X, Zhu S, Huang H . A Peptide Encoded by a Putative lncRNA HOXB-AS3 Suppresses Colon Cancer Growth. Mol Cell. 2017; 68(1):171-184.e6. DOI: 10.1016/j.molcel.2017.09.015. View

11.

Huang W, Li H, Yu Q, Xiao W, Wang D . LncRNA-mediated DNA methylation: an emerging mechanism in cancer and beyond. J Exp Clin Cancer Res. 2022; 41(1):100. PMC: 8922926. DOI: 10.1186/s13046-022-02319-z. View

12.

Zhang N, Wang B, Ma C, Zeng J, Wang T, Han L . LINC00240 in the 6p22.1 risk locus promotes gastric cancer progression through USP10-mediated DDX21 stabilization. J Exp Clin Cancer Res. 2023; 42(1):89. PMC: 10111703. DOI: 10.1186/s13046-023-02654-9. View

13.

Alsayed R, Sheikhan K, Alam M, Buddenkotte J, Steinhoff M, Uddin S . Epigenetic programing of cancer stemness by transcription factors-non-coding RNAs interactions. Semin Cancer Biol. 2023; 92:74-83. DOI: 10.1016/j.semcancer.2023.04.005. View

14.

Di Cerbo V, Schneider R . Cancers with wrong HATs: the impact of acetylation. Brief Funct Genomics. 2013; 12(3):231-43. DOI: 10.1093/bfgp/els065. View

15.

Ma H, Hu T, Tao W, Tong J, Han Z, Herndler-Brandstetter D . A lncRNA from an inflammatory bowel disease risk locus maintains intestinal host-commensal homeostasis. Cell Res. 2023; 33(5):372-388. PMC: 10156687. DOI: 10.1038/s41422-023-00790-7. View

16.

Cheng X, Zeng Z, Yang H, Chen Y, Liu Y, Zhou X . Novel cuproptosis-related long non-coding RNA signature to predict prognosis in prostate carcinoma. BMC Cancer. 2023; 23(1):105. PMC: 9887873. DOI: 10.1186/s12885-023-10584-0. View

17.

Bi Y, Wang Y, Sun X . Recent Advances of LncRNA H19 in Diabetes LncRNA H19 in Diabetes. Horm Metab Res. 2022; 54(4):212-219. DOI: 10.1055/a-1769-5032. View

18.

Larabi A, Barnich N, Nguyen H . Emerging Role of Exosomes in Diagnosis and Treatment of Infectious and Inflammatory Bowel Diseases. Cells. 2020; 9(5). PMC: 7290936. DOI: 10.3390/cells9051111. View

19.

Shi L, Duan R, Sun Z, Jia Q, Wu W, Wang F . LncRNA GLTC targets LDHA for succinylation and enzymatic activity to promote progression and radioiodine resistance in papillary thyroid cancer. Cell Death Differ. 2023; 30(6):1517-1532. PMC: 10244348. DOI: 10.1038/s41418-023-01157-6. View

20.

Moran V, Perera R, Khalil A . Emerging functional and mechanistic paradigms of mammalian long non-coding RNAs. Nucleic Acids Res. 2012; 40(14):6391-400. PMC: 3413108. DOI: 10.1093/nar/gks296. View