Remyelinating Oligodendrocyte Precursor Cell MiRNAs from the Sfmbt2 Cluster Promote Cell Cycle Arrest and Differentiation

Overview

Journal J Neurosci

Specialty Neurology

Date 2016 Feb 5

PMID 26843650

Citations 20

Authors

Nicholas J Kuypers

Andrew N Bankston

Russell M Howard

Jason E Beare

Scott R Whittemore

Affiliations

Soon will be listed here.

Abstract

Significance Statement: This work describes the role of oligodendrocyte progenitor cell (OPC) microRNAs (miRNAs) during remyelination and development in vivo and differentiation in vitro. This work highlights the importance of miRNAs to OPC biology and describes miR-297c-5p, a novel regulator of OPC function. In addition, we identified CCNT2 as a functional target, thus providing a mechanism by which miR-297c-5p imparts its effects on differentiation. These data are important, given our lack of understanding of OPC miRNA regulatory networks and their potential clinical value. Therefore, efforts to understand the role of miR-297c-5p in pathological conditions and its potential for facilitating repair may provide future therapeutic strategies to treat demyelination.

Citing Articles

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