The Role of MicroRNAs in Repair Processes in Multiple Sclerosis

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2020 Jul 26

PMID 32708794

Citations 14

Authors

Conor P Duffy

Claire E McCoy

Affiliations

Soon will be listed here.

Abstract

Multiple sclerosis (MS) is an autoimmune disorder characterised by demyelination of central nervous system neurons with subsequent damage, cell death and disability. While mechanisms exist in the CNS to repair this damage, they are disrupted in MS and currently there are no treatments to address this deficit. In recent years, increasing attention has been paid to the influence of the small, non-coding RNA molecules, microRNAs (miRNAs), in autoimmune disorders, including MS. In this review, we examine the role of miRNAs in remyelination in the different cell types that contribute to MS. We focus on key miRNAs that have a central role in mediating the repair process, along with several more that play either secondary or inhibitory roles in one or more aspects. Finally, we consider the current state of miRNAs as therapeutic targets in MS, acknowledging current challenges and potential strategies to overcome them in developing effective novel therapeutics to enhance repair mechanisms in MS.

Citing Articles

The role of microRNAs involved in the disorder of blood-brain barrier in the pathogenesis of multiple sclerosis.

Emami Nejad A, Zadeh S, Nickho H, Sadoogh Abbasian A, Forouzan A, Ahmadlou M Front Immunol. 2024; 14:1281567.

PMID: 38193092 PMC: 10773759. DOI: 10.3389/fimmu.2023.1281567.

MicroRNAs Associated with Disability Progression and Clinical Activity in Multiple Sclerosis Patients Treated with Glatiramer Acetate.

Casanova I, Dominguez-Mozo M, De Torres L, Aladro-Benito Y, Garcia-Martinez A, Gomez P Biomedicines. 2023; 11(10).

PMID: 37893133 PMC: 10604830. DOI: 10.3390/biomedicines11102760.

Remyelination in multiple sclerosis from the miRNA perspective.

Maciak K, Dziedzic A, Saluk J Front Mol Neurosci. 2023; 16:1199313.

PMID: 37333618 PMC: 10270307. DOI: 10.3389/fnmol.2023.1199313.

piRNA and miRNA Can Suppress the Expression of Multiple Sclerosis Candidate Genes.

Kamenova S, Sharapkhanova A, Akimniyazova A, Kuzhybayeva K, Kondybayeva A, Rakhmetullina A Nanomaterials (Basel). 2023; 13(1).

PMID: 36615932 PMC: 9823834. DOI: 10.3390/nano13010022.

Treatment and Relapse Prevention of Typical and Atypical Optic Neuritis.

Saitakis G, Chwalisz B Int J Mol Sci. 2022; 23(17).

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References

Louloupi A, Vang Orom U . Inhibiting Pri-miRNA Processing with Target Site Blockers. Methods Mol Biol. 2018; 1823:63-68. DOI: 10.1007/978-1-4939-8624-8_6. View

Galloway D, Blandford S, Berry T, Williams J, Stefanelli M, Ploughman M . miR-223 promotes regenerative myeloid cell phenotype and function in the demyelinated central nervous system. Glia. 2018; 67(5):857-869. DOI: 10.1002/glia.23576. View

Nguyen D, Chang S . Development of Novel Therapeutic Agents by Inhibition of Oncogenic MicroRNAs. Int J Mol Sci. 2017; 19(1). PMC: 5796015. DOI: 10.3390/ijms19010065. View

Galloway D, Williams J, Moore C . Effects of fumarates on inflammatory human astrocyte responses and oligodendrocyte differentiation. Ann Clin Transl Neurol. 2017; 4(6):381-391. PMC: 5454401. DOI: 10.1002/acn3.414. View

Long H, Wu R, Liu C, Xiong F, Xu Z, He D . MiR-125a-5p Regulates Vitamin D Receptor Expression in a Mouse Model of Experimental Autoimmune Encephalomyelitis. Neurosci Bull. 2019; 36(2):110-120. PMC: 6977816. DOI: 10.1007/s12264-019-00418-0. View

Orom U, Nielsen F, Lund A . MicroRNA-10a binds the 5'UTR of ribosomal protein mRNAs and enhances their translation. Mol Cell. 2008; 30(4):460-71. DOI: 10.1016/j.molcel.2008.05.001. View

Sofroniew M, Vinters H . Astrocytes: biology and pathology. Acta Neuropathol. 2009; 119(1):7-35. PMC: 2799634. DOI: 10.1007/s00401-009-0619-8. View

Zhao X, He X, Han X, Yu Y, Ye F, Chen Y . MicroRNA-mediated control of oligodendrocyte differentiation. Neuron. 2010; 65(5):612-26. PMC: 2855245. DOI: 10.1016/j.neuron.2010.02.018. View

Buller B, Chopp M, Ueno Y, Zhang L, Zhang R, Morris D . Regulation of serum response factor by miRNA-200 and miRNA-9 modulates oligodendrocyte progenitor cell differentiation. Glia. 2012; 60(12):1906-14. PMC: 3474880. DOI: 10.1002/glia.22406. View

10.

Bach Sondergaard H, Hesse D, Krakauer M, Soelberg Sorensen P, Sellebjerg F . Differential microRNA expression in blood in multiple sclerosis. Mult Scler. 2013; 19(14):1849-57. DOI: 10.1177/1352458513490542. View

11.

Pusic A, Pusic K, Kraig R . What are exosomes and how can they be used in multiple sclerosis therapy?. Expert Rev Neurother. 2014; 14(4):353-5. PMC: 4090348. DOI: 10.1586/14737175.2014.890893. View

12.

Kotter M, Li W, Zhao C, Franklin R . Myelin impairs CNS remyelination by inhibiting oligodendrocyte precursor cell differentiation. J Neurosci. 2006; 26(1):328-32. PMC: 6674302. DOI: 10.1523/JNEUROSCI.2615-05.2006. View

13.

Tripathi A, Volsko C, Datta U, Regev K, Dutta R . Expression of disease-related miRNAs in white-matter lesions of progressive multiple sclerosis brains. Ann Clin Transl Neurol. 2019; 6(5):854-862. PMC: 6530016. DOI: 10.1002/acn3.750. View

14.

Diao H, Low W, Milbreta U, Lu Q, Chew S . Nanofiber-mediated microRNA delivery to enhance differentiation and maturation of oligodendroglial precursor cells. J Control Release. 2015; 208:85-92. PMC: 4779954. DOI: 10.1016/j.jconrel.2015.03.005. View

15.

Afrang N, Tavakoli R, Tasharrofi N, Alian A, Naderi Sohi A, Kabiri M . A critical role for miR-184 in the fate determination of oligodendrocytes. Stem Cell Res Ther. 2019; 10(1):112. PMC: 6440085. DOI: 10.1186/s13287-019-1208-y. View

16.

Saenz-Cuesta M, Alberro A, Munoz-Culla M, Osorio-Querejeta I, Fernandez-Mercado M, Lopetegui I . The First Dose of Fingolimod Affects Circulating Extracellular Vesicles in Multiple Sclerosis Patients. Int J Mol Sci. 2018; 19(8). PMC: 6121302. DOI: 10.3390/ijms19082448. View

17.

Lewkowicz P, Cwiklinska H, Mycko M, Cichalewska M, Domowicz M, Lewkowicz N . Dysregulated RNA-Induced Silencing Complex (RISC) Assembly within CNS Corresponds with Abnormal miRNA Expression during Autoimmune Demyelination. J Neurosci. 2015; 35(19):7521-37. PMC: 6705439. DOI: 10.1523/JNEUROSCI.4794-14.2015. View

18.

Locatelli G, Theodorou D, Kendirli A, Jordao M, Staszewski O, Phulphagar K . Mononuclear phagocytes locally specify and adapt their phenotype in a multiple sclerosis model. Nat Neurosci. 2018; 21(9):1196-1208. DOI: 10.1038/s41593-018-0212-3. View

19.

Holley J, Gveric D, Newcombe J, Cuzner M, Gutowski N . Astrocyte characterization in the multiple sclerosis glial scar. Neuropathol Appl Neurobiol. 2003; 29(5):434-44. DOI: 10.1046/j.1365-2990.2003.00491.x. View

20.

Lin H, Nikolic I, Yang J, Castillo L, Deng N, Chan C . MicroRNAs as potential therapeutics to enhance chemosensitivity in advanced prostate cancer. Sci Rep. 2018; 8(1):7820. PMC: 5959911. DOI: 10.1038/s41598-018-26050-y. View