The Role of MicroRNAs in Repair Processes in Multiple Sclerosis
Overview
Biophysics
Cell Biology
Molecular Biology
Authors
Affiliations
Multiple sclerosis (MS) is an autoimmune disorder characterised by demyelination of central nervous system neurons with subsequent damage, cell death and disability. While mechanisms exist in the CNS to repair this damage, they are disrupted in MS and currently there are no treatments to address this deficit. In recent years, increasing attention has been paid to the influence of the small, non-coding RNA molecules, microRNAs (miRNAs), in autoimmune disorders, including MS. In this review, we examine the role of miRNAs in remyelination in the different cell types that contribute to MS. We focus on key miRNAs that have a central role in mediating the repair process, along with several more that play either secondary or inhibitory roles in one or more aspects. Finally, we consider the current state of miRNAs as therapeutic targets in MS, acknowledging current challenges and potential strategies to overcome them in developing effective novel therapeutics to enhance repair mechanisms in MS.
Emami Nejad A, Zadeh S, Nickho H, Sadoogh Abbasian A, Forouzan A, Ahmadlou M Front Immunol. 2024; 14:1281567.
PMID: 38193092 PMC: 10773759. DOI: 10.3389/fimmu.2023.1281567.
Casanova I, Dominguez-Mozo M, De Torres L, Aladro-Benito Y, Garcia-Martinez A, Gomez P Biomedicines. 2023; 11(10).
PMID: 37893133 PMC: 10604830. DOI: 10.3390/biomedicines11102760.
Remyelination in multiple sclerosis from the miRNA perspective.
Maciak K, Dziedzic A, Saluk J Front Mol Neurosci. 2023; 16:1199313.
PMID: 37333618 PMC: 10270307. DOI: 10.3389/fnmol.2023.1199313.
piRNA and miRNA Can Suppress the Expression of Multiple Sclerosis Candidate Genes.
Kamenova S, Sharapkhanova A, Akimniyazova A, Kuzhybayeva K, Kondybayeva A, Rakhmetullina A Nanomaterials (Basel). 2023; 13(1).
PMID: 36615932 PMC: 9823834. DOI: 10.3390/nano13010022.
Treatment and Relapse Prevention of Typical and Atypical Optic Neuritis.
Saitakis G, Chwalisz B Int J Mol Sci. 2022; 23(17).
PMID: 36077167 PMC: 9456305. DOI: 10.3390/ijms23179769.