Dynamics of the Actin Cytoskeleton Mediates Receptor Cross Talk: An Emerging Concept in Tuning Receptor Signaling

Overview

Journal J Cell Biol

Specialty Cell Biology

Date 2016 Feb 3

PMID 26833785

Citations 71

Authors

Pieta K Mattila

Facundo D Batista

Bebhinn Treanor

Affiliations

Soon will be listed here.

Abstract

Recent evidence implicates the actin cytoskeleton in the control of receptor signaling. This may be of particular importance in the context of immune receptors, such as the B cell receptor, where dysregulated signaling can result in autoimmunity and malignancy. Here, we discuss the role of the actin cytoskeleton in controlling receptor compartmentalization, dynamics, and clustering as a means to regulate receptor signaling through controlling the interactions with protein partners. We propose that the actin cytoskeleton is a point of integration for receptor cross talk through modulation of protein dynamics and clustering. We discuss the implication of this cross talk via the cytoskeleton for both ligand-induced and low-level constitutive (tonic) signaling necessary for immune cell survival.

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