Facundo D Batista
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Explore the profile of Facundo D Batista including associated specialties, affiliations and a list of published articles.
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Articles
86
Citations
4727
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Recent Articles
1.
Caniels T, Medina-Ramirez M, Zhang S, Kratochvil S, Xian Y, Koo J, et al.
Sci Immunol
. 2024 Aug;
9(98):eadk9550.
PMID: 39213338
Eliciting potent and broadly neutralizing antibodies (bnAbs) is a major goal in HIV-1 vaccine development. Here, we describe how germline-targeting immunogen BG505 SOSIP germline trimer 1.1 (GT1.1), generated through structure-based...
2.
Schiffner T, Phung I, Ray R, Irimia A, Tian M, Swanson O, et al.
Nat Immunol
. 2024 Jun;
25(7):1307.
PMID: 38877179
No abstract available.
3.
Ray R, Schiffner T, Wang X, Yan Y, Rantalainen K, Lee C, et al.
Nat Immunol
. 2024 May;
25(6):1083-1096.
PMID: 38816616
Current prophylactic human immunodeficiency virus 1 (HIV-1) vaccine research aims to elicit broadly neutralizing antibodies (bnAbs). Membrane-proximal external region (MPER)-targeting bnAbs, such as 10E8, provide exceptionally broad neutralization, but some...
4.
Schiffner T, Phung I, Ray R, Irimia A, Tian M, Swanson O, et al.
Nat Immunol
. 2024 May;
25(6):1073-1082.
PMID: 38816615
A key barrier to the development of vaccines that induce broadly neutralizing antibodies (bnAbs) against human immunodeficiency virus (HIV) and other viruses of high antigenic diversity is the design of...
5.
Wang X, Cottrell C, Hu X, Ray R, Bottermann M, Villavicencio P, et al.
Sci Immunol
. 2024 May;
9(95):eadn0622.
PMID: 38753808
Germline-targeting (GT) protein immunogens to induce VRC01-class broadly neutralizing antibodies (bnAbs) to the CD4-binding site of the HIV envelope (Env) have shown promise in clinical trials. Here, we preclinically validated...
6.
Xie Z, Lin Y, Steichen J, Ozorowski G, Kratochvil S, Ray R, et al.
Science
. 2024 May;
384(6697):eadk0582.
PMID: 38753770
Germline-targeting (GT) HIV vaccine strategies are predicated on deriving broadly neutralizing antibodies (bnAbs) through multiple boost immunogens. However, as the recruitment of memory B cells (MBCs) to germinal centers (GCs)...
7.
Ray R, Nait Mohamed F, Maurer D, Huang J, Alpay B, Ronsard L, et al.
Immunity
. 2024 Apr;
57(5):1141-1159.e11.
PMID: 38670113
Broadly neutralizing antibodies (bnAbs) targeting the hemagglutinin (HA) stem of influenza A viruses (IAVs) tend to be effective against either group 1 or group 2 viral diversity. In rarer cases,...
8.
Giguere S, Wang X, Huber S, Xu L, Warner J, Weldon S, et al.
Science
. 2024 Jan;
383(6679):205-211.
PMID: 38207021
Antibodies are produced at high rates to provide immunoprotection, which puts pressure on the B cell translational machinery. Here, we identified a pattern of codon usage conserved across antibody genes....
9.
Tripathi P, Bender M, Lei H, Da Silva Pereira L, Shen C, Bonilla B, et al.
Structure
. 2023 Mar;
31(4):480-491.e4.
PMID: 36931276
Monoclonal antibody L9 recognizes the Plasmodium falciparum circumsporozoite protein (PfCSP) and is highly protective following controlled human malaria challenge. To gain insight into its function, we determined cryoelectron microscopy (cryo-EM)...
10.
Luo S, Jing C, Ye A, Kratochvil S, Cottrell C, Koo J, et al.
Proc Natl Acad Sci U S A
. 2022 Dec;
120(1):e2217883120.
PMID: 36574685
Antibody heavy chain (HC) and light chain (LC) variable region exons are assembled by V(D)J recombination. V(D)J junctional regions encode complementarity-determining-region 3 (CDR3), an antigen-contact region immensely diversified through nontemplated...