Filamins As Integrators of Cell Mechanics and Signalling

Overview

Journal Nat Rev Mol Cell Biol

Specialties Cell Biology
Molecular Biology

Date 2001 Mar 17

PMID 11252955

Citations 414

Authors

T P Stossel

J Condeelis

L Cooley

J H Hartwig

A Noegel

M Schleicher

S S Shapiro

Affiliations

Soon will be listed here.

Abstract

Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin webs and link them to cellular membranes. They integrate cellular architectural and signalling functions and are essential for fetal development and cell locomotion. Here, we describe the history, structure and function of this group of proteins.

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