TLX-Its Emerging Role for Neurogenesis in Health and Disease

Overview

Journal Mol Neurobiol

Specialties Molecular Biology
Neurology

Date 2016 Jan 8

PMID 26738856

Citations 10

Authors

Praveen K Sobhan

Keiko Funa

Affiliations

Soon will be listed here.

Abstract

The orphan nuclear receptor TLX, also called NR2E1, is a factor important in the regulation of neural stem cell (NSC) self-renewal, neurogenesis, and maintenance. As a transcription factor, TLX is vital for the expression of genes implicated in neurogenesis, such as DNA replication, cell cycle, adhesion and migration. It acts by way of repressing or activating target genes, as well as controlling protein-protein interactions. Growing evidence suggests that dysregulated TLX acts in the initiation and progression of human disorders of the nervous system. This review describes recent knowledge about TLX expression, structure, targets, and biological functions, relevant to maintaining adult neural stem cells related to both neuropsychiatric conditions and certain nervous system tumours.

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