Nuclear Receptors in Neural Stem/progenitor Cell Homeostasis

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2017 Jun 23

PMID 28638936

Citations 10

Authors

Dimitrios Gkikas

Matina Tsampoula

Panagiotis K Politis

Affiliations

Soon will be listed here.

Abstract

In the central nervous system, embryonic and adult neural stem/progenitor cells (NSCs) generate the enormous variety and huge numbers of neuronal and glial cells that provide structural and functional support in the brain and spinal cord. Over the last decades, nuclear receptors and their natural ligands have emerged as critical regulators of NSC homeostasis during embryonic development and adult life. Furthermore, substantial progress has been achieved towards elucidating the molecular mechanisms of nuclear receptors action in proliferative and differentiation capacities of NSCs. Aberrant expression or function of nuclear receptors in NSCs also contributes to the pathogenesis of various nervous system diseases. Here, we review recent advances in our understanding of the regulatory roles of steroid, non-steroid, and orphan nuclear receptors in NSC fate decisions. These studies establish nuclear receptors as key therapeutic targets in brain diseases.

Citing Articles

Zebrafish as an emerging model to study estrogen receptors in neural development.

Boueid M, El-Hage O, Schumacher M, Degerny C, Tawk M Front Endocrinol (Lausanne). 2023; 14:1240018.

PMID: 37664862 PMC: 10469878. DOI: 10.3389/fendo.2023.1240018.

Nuclear receptor NR5A2 negatively regulates cell proliferation and tumor growth in nervous system malignancies.

Gkikas D, Stellas D, Polissidis A, Manolakou T, Kokotou M, Kokotos G Proc Natl Acad Sci U S A. 2021; 118(39).

PMID: 34561301 PMC: 8488649. DOI: 10.1073/pnas.2015243118.

PPAR Gamma and Viral Infections of the Brain.

Layrolle P, Payoux P, Chavanas S Int J Mol Sci. 2021; 22(16).

PMID: 34445581 PMC: 8396218. DOI: 10.3390/ijms22168876.

REV-ERB Agonist SR9009 Regulates the Proliferation and Neurite Outgrowth/Suppression of Cultured Rat Adult Hippocampal Neural Stem/Progenitor Cells in a Concentration-Dependent Manner.

Shimozaki K Cell Mol Neurobiol. 2021; 42(6):1765-1776.

PMID: 33599915 PMC: 11421744. DOI: 10.1007/s10571-021-01053-y.

A seven-nuclear receptor-based prognostic signature in breast cancer.

Wu F, Chen W, Kang X, Jin L, Bai J, Zhang H Clin Transl Oncol. 2020; 23(7):1292-1303.

PMID: 33210236 DOI: 10.1007/s12094-020-02517-1.

References

Cheng S . Thyroid hormone receptor mutations and disease: beyond thyroid hormone resistance. Trends Endocrinol Metab. 2005; 16(4):176-82. DOI: 10.1016/j.tem.2005.03.008. View

Morales-Garcia J, Luna-Medina R, Alfaro-Cervello C, Cortes-Canteli M, Santos A, Garcia-Verdugo J . Peroxisome proliferator-activated receptor γ ligands regulate neural stem cell proliferation and differentiation in vitro and in vivo. Glia. 2010; 59(2):293-307. DOI: 10.1002/glia.21101. View

Kishi Y, Takahashi J, Koyanagi M, Morizane A, Okamoto Y, Horiguchi S . Estrogen promotes differentiation and survival of dopaminergic neurons derived from human neural stem cells. J Neurosci Res. 2004; 79(3):279-86. DOI: 10.1002/jnr.20362. View

Keilhoff G, Grecksch G, Becker A . Haloperidol normalized prenatal vitamin D depletion-induced reduction of hippocampal cell proliferation in adult rats. Neurosci Lett. 2010; 476(2):94-8. DOI: 10.1016/j.neulet.2010.04.010. View

Eyles D, Burne T, McGrath J . Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease. Front Neuroendocrinol. 2012; 34(1):47-64. DOI: 10.1016/j.yfrne.2012.07.001. View

Sobhan P, Funa K . TLX-Its Emerging Role for Neurogenesis in Health and Disease. Mol Neurobiol. 2016; 54(1):272-280. PMC: 5219886. DOI: 10.1007/s12035-015-9608-1. View

Jacobs F, van Erp S, van der Linden A, Von Oerthel L, Burbach J, Smidt M . Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression. Development. 2009; 136(4):531-40. DOI: 10.1242/dev.029769. View

Qiu Y, Pereira F, Demayo F, Lydon J, Tsai S, Tsai M . Null mutation of mCOUP-TFI results in defects in morphogenesis of the glossopharyngeal ganglion, axonal projection, and arborization. Genes Dev. 1997; 11(15):1925-37. PMC: 316414. DOI: 10.1101/gad.11.15.1925. View

Tran P, Zhang X, Salbert G, Hermann T, Lehmann J, Pfahl M . COUP orphan receptors are negative regulators of retinoic acid response pathways. Mol Cell Biol. 1992; 12(10):4666-76. PMC: 360393. DOI: 10.1128/mcb.12.10.4666-4676.1992. View

10.

Park K, Lee R, Kang S, Han S, Park K, Yang K . Neuronal differentiation of embryonic midbrain cells by upregulation of peroxisome proliferator-activated receptor-gamma via the JNK-dependent pathway. Exp Cell Res. 2004; 297(2):424-33. DOI: 10.1016/j.yexcr.2004.03.034. View

11.

Chetty S, Friedman A, Taravosh-Lahn K, Kirby E, Mirescu C, Guo F . Stress and glucocorticoids promote oligodendrogenesis in the adult hippocampus. Mol Psychiatry. 2014; 19(12):1275-1283. PMC: 4128957. DOI: 10.1038/mp.2013.190. View

12.

Faedo A, Tomassy G, Ruan Y, Teichmann H, Krauss S, Pleasure S . COUP-TFI coordinates cortical patterning, neurogenesis, and laminar fate and modulates MAPK/ERK, AKT, and beta-catenin signaling. Cereb Cortex. 2008; 18(9):2117-31. PMC: 2733307. DOI: 10.1093/cercor/bhm238. View

13.

Saga Y, Kobayashi M, Ohta H, Murai N, Nakai N, Oshima M . Impaired extrapyramidal function caused by the targeted disruption of retinoid X receptor RXRgamma1 isoform. Genes Cells. 1999; 4(4):219-28. DOI: 10.1046/j.1365-2443.1999.00253.x. View

14.

Crochemore C, Lu J, Wu Y, Liposits Z, Sousa N, Holsboer F . Direct targeting of hippocampal neurons for apoptosis by glucocorticoids is reversible by mineralocorticoid receptor activation. Mol Psychiatry. 2005; 10(8):790-8. DOI: 10.1038/sj.mp.4001679. View

15.

Alavian K, Jeddi S, Naghipour S, Nabili P, Licznerski P, Tierney T . The lifelong maintenance of mesencephalic dopaminergic neurons by Nurr1 and engrailed. J Biomed Sci. 2014; 21:27. PMC: 3998737. DOI: 10.1186/1423-0127-21-27. View

16.

Johe K, Hazel T, Muller T, McKay R . Single factors direct the differentiation of stem cells from the fetal and adult central nervous system. Genes Dev. 1996; 10(24):3129-40. DOI: 10.1101/gad.10.24.3129. View

17.

Sattler U, Samochocki M, Maelicke A, Zechel C . The expression level of the orphan nuclear receptor GCNF (germ cell nuclear factor) is critical for neuronal differentiation. Mol Endocrinol. 2004; 18(11):2714-26. DOI: 10.1210/me.2004-0251. View

18.

Paschaki M, Cammas L, Muta Y, Matsuoka Y, Mak S, Rataj-Baniowska M . Retinoic acid regulates olfactory progenitor cell fate and differentiation. Neural Dev. 2013; 8:13. PMC: 3717070. DOI: 10.1186/1749-8104-8-13. View

19.

Yan Z, Jetten A . Characterization of the repressor function of the nuclear orphan receptor retinoid receptor-related testis-associated receptor/germ cell nuclear factor. J Biol Chem. 2000; 275(45):35077-85. DOI: 10.1074/jbc.M005566200. View

20.

Fernandez M, Pirondi S, Manservigi M, Giardino L, Calza L . Thyroid hormone participates in the regulation of neural stem cells and oligodendrocyte precursor cells in the central nervous system of adult rat. Eur J Neurosci. 2004; 20(8):2059-70. DOI: 10.1111/j.1460-9568.2004.03664.x. View