Epidemiologic Studies of the Human Microbiome and Cancer

Overview

Journal Br J Cancer

Specialty Oncology

Date 2016 Jan 6

PMID 26730578

Citations 102

Authors

Emily Vogtmann

James J Goedert

Affiliations

Soon will be listed here.

Abstract

The human microbiome, which includes the collective genome of all bacteria, archaea, fungi, protists, and viruses found in and on the human body, is altered in many diseases and may substantially affect cancer risk. Previously detected associations of individual bacteria (e.g., Helicobacter pylori), periodontal disease, and inflammation with specific cancers have motivated studies considering the association between the human microbiome and cancer risk. This short review summarises microbiome research, focusing on published epidemiological associations with gastric, oesophageal, hepatobiliary, pancreatic, lung, colorectal, and other cancers. Large, prospective studies of the microbiome that employ multidisciplinary laboratory and analysis methods, as well as rigorous validation of case status, are likely to yield translational opportunities to reduce cancer morbidity and mortality by improving prevention, screening, and treatment.

Citing Articles

Inflammation, microbiota, and pancreatic cancer.

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Non-coding RNAs in bladder cancer, a bridge between gut microbiota and host?.

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Gastric microbiome composition accompanied with the related DNA methylation anomaly.

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The Effects of Aspirin Intervention on Inflammation-Associated Lingual Bacteria: A Pilot Study from a Randomized Clinical Trial.

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Microbiome of esophageal endoscopic wash samples is associated with resident flora in the esophagus and incidence of cancer.

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