Prognostic Value of Peripheral Blood Lymphocyte-to-monocyte Ratio in Patients with Solid Tumors: a Meta-analysis

Overview

Journal Onco Targets Ther

Publisher Dove Medical Press

Specialty Oncology

Date 2016 Jan 6

PMID 26730202

Citations 35

Authors

Jun-Jie Teng

Jian Zhang

Tian-Yi Zhang

Shu Zhang

Bao-Sheng Li

Affiliations

Soon will be listed here.

Abstract

Background: Although accumulating evidence suggests peripheral blood lymphocyte-to-monocyte ratio (LMR) could act as a prognosis predictor in various tumors, the prognostic value of LMR still remains controversial. We carried out this meta-analysis to evaluate the association of pretreatment LMR with survival outcomes in patients with solid tumors.

Methods: Eligible studies were collected and extracted by searching PubMed and Embase databases up to June 3, 2015. The pooled hazard ratios (HRs) and their 95% confidence intervals (CIs) were computed to assess the prognostic value of LMR quantitatively.

Results: Eighteen studies with a total of 8,377 participants were enrolled in this meta-analysis. Our findings indicated that elevated pre-treatment LMR predicted a significantly favorable overall survival (HR=0.59, 95% CI: 0.53-0.67) and disease-free survival (HR=0.74, 95% CI: 0.68-0.80) in solid tumor patients. Subgroup analyses revealed that enhanced LMR was significantly associated with favorable overall survival in patients with digestive system cancers (HR=0.63, 95% CI: 0.49-0.81), urinary tract tumors (HR=0.66, 95% CI: 0.52-0.84), lung cancer (HR=0.62, 95% CI: 0.54-0.72), and nasopharyngeal carcinoma (HR=0.50, 95% CI: 0.43-0.57).

Conclusion: This meta-analysis showed that enhanced LMR may indicate a favorable prognosis in patients with solid tumors.

Citing Articles

Expression and Clinical Significance of Lymphocyte Subpopulations and Peripheral Inflammatory Markers in Glioma.

Zhou C, Xu L, Geng M, Hu S J Inflamm Res. 2024; 17:9423-9451.

PMID: 39600678 PMC: 11590653. DOI: 10.2147/JIR.S474577.

Platelet-to-lymphocyte, neutrophil-to-lymphocyte and lymphocyte-to-monocyte ratios are related to cancer-related fatigue and quality of life in patients with cancer: a cross-sectional study.

Yu H, Tan L, Xue B, Feng L, Fang P, Meng X BMJ Open. 2023; 13(12):e075398.

PMID: 38056937 PMC: 10711903. DOI: 10.1136/bmjopen-2023-075398.

Prognostic value and model construction of preoperative inflammatory markers in patients with metastatic renal cell carcinoma.

Wang J, Ye J, Zhao X, Li X, Ma X World J Surg Oncol. 2023; 21(1):211.

PMID: 37480143 PMC: 10360324. DOI: 10.1186/s12957-023-03110-w.

Platelet-derived TLT-1 promotes tumor progression by suppressing CD8+ T cells.

Tyagi T, Jain K, Yarovinsky T, Chiorazzi M, Du J, Castro C J Exp Med. 2022; 220(1).

PMID: 36305874 DOI: 10.1084/jem.20212218.

Lower Platelet-to-Lymphocyte Ratio Was Associated with Poor Prognosis for Newborn Patients in NICU.

Tang Y, Teng Y, Xu L, Xu G, Chen D, Jin X Medicina (Kaunas). 2022; 58(10).

PMID: 36295557 PMC: 9612288. DOI: 10.3390/medicina58101397.

References

Tierney J, Stewart L, Ghersi D, Burdett S, Sydes M . Practical methods for incorporating summary time-to-event data into meta-analysis. Trials. 2007; 8:16. PMC: 1920534. DOI: 10.1186/1745-6215-8-16. View

Hutterer G, Sobolev N, Ehrlich G, Gutschi T, Stojakovic T, Mannweiler S . Pretreatment lymphocyte-monocyte ratio as a potential prognostic factor in a cohort of patients with upper tract urothelial carcinoma. J Clin Pathol. 2015; 68(5):351-5. DOI: 10.1136/jclinpath-2014-202658. View

Qi Q, Geng Y, Sun M, Wang P, Chen Z . Clinical implications of systemic inflammatory response markers as independent prognostic factors for advanced pancreatic cancer. Pancreatology. 2015; 15(2):145-50. DOI: 10.1016/j.pan.2014.12.004. View

Mlecnik B, Tosolini M, Kirilovsky A, Berger A, Bindea G, Meatchi T . Histopathologic-based prognostic factors of colorectal cancers are associated with the state of the local immune reaction. J Clin Oncol. 2011; 29(6):610-8. DOI: 10.1200/JCO.2010.30.5425. View

Coussens L, Werb Z . Inflammation and cancer. Nature. 2002; 420(6917):860-7. PMC: 2803035. DOI: 10.1038/nature01322. View

Leek R, Harris A . Tumor-associated macrophages in breast cancer. J Mammary Gland Biol Neoplasia. 2002; 7(2):177-89. DOI: 10.1023/a:1020304003704. View

Deng Q, He B, Liu X, Yue J, Ying H, Pan Y . Prognostic value of pre-operative inflammatory response biomarkers in gastric cancer patients and the construction of a predictive model. J Transl Med. 2015; 13:66. PMC: 4343078. DOI: 10.1186/s12967-015-0409-0. View

Ubukata H, Motohashi G, Tabuchi T, Nagata H, Konishi S, Tabuchi T . Evaluations of interferon-γ/interleukin-4 ratio and neutrophil/lymphocyte ratio as prognostic indicators in gastric cancer patients. J Surg Oncol. 2010; 102(7):742-7. DOI: 10.1002/jso.21725. View

Xiong M, Elson G, Legarda D, Leibovich S . Production of vascular endothelial growth factor by murine macrophages: regulation by hypoxia, lactate, and the inducible nitric oxide synthase pathway. Am J Pathol. 1998; 153(2):587-98. PMC: 1852978. DOI: 10.1016/S0002-9440(10)65601-5. View

10.

Li J, Jiang R, Liu W, Liu Q, Xu M, Feng Q . A large cohort study reveals the association of elevated peripheral blood lymphocyte-to-monocyte ratio with favorable prognosis in nasopharyngeal carcinoma. PLoS One. 2014; 8(12):e83069. PMC: 3873908. DOI: 10.1371/journal.pone.0083069. View

11.

Stotz M, Pichler M, Absenger G, Szkandera J, Arminger F, Schaberl-Moser R . The preoperative lymphocyte to monocyte ratio predicts clinical outcome in patients with stage III colon cancer. Br J Cancer. 2013; 110(2):435-40. PMC: 3899781. DOI: 10.1038/bjc.2013.785. View

12.

Wei X, Huang F, Wei Y, Jing H, Xie M, Hao X . Low lymphocyte-to-monocyte ratio predicts unfavorable prognosis in non-germinal center type diffuse large B-cell lymphoma. Leuk Res. 2014; 38(6):694-8. DOI: 10.1016/j.leukres.2014.03.013. View

13.

Xiao W, Zhang L, You K, Huang R, Yu X, Ding P . A Low Lymphocyte-to-Monocyte Ratio Predicts Unfavorable Prognosis in Pathological T3N0 Rectal Cancer Patients Following Total Mesorectal Excision. J Cancer. 2015; 6(7):616-22. PMC: 4466410. DOI: 10.7150/jca.11727. View

14.

Balermpas P, Rodel F, Weiss C, Rodel C, Fokas E . Tumor-infiltrating lymphocytes favor the response to chemoradiotherapy of head and neck cancer. Oncoimmunology. 2014; 3(1):e27403. PMC: 3976983. DOI: 10.4161/onci.27403. View

15.

Zhang G, Zhu Y, Luo L, Wan F, Zhu Y, Sun L . Preoperative lymphocyte-monocyte and platelet-lymphocyte ratios as predictors of overall survival in patients with bladder cancer undergoing radical cystectomy. Tumour Biol. 2015; 36(11):8537-43. DOI: 10.1007/s13277-015-3613-x. View

16.

Torre L, Bray F, Siegel R, Ferlay J, Lortet-Tieulent J, Jemal A . Global cancer statistics, 2012. CA Cancer J Clin. 2015; 65(2):87-108. DOI: 10.3322/caac.21262. View

17.

Lee S, Kim S, Kim Y, Lee S, Park S . Prognostic significance of preoperative peripheral blood monocyte ratio in patients with hepatocellular carcinoma. World J Surg. 2014; 38(9):2377-85. DOI: 10.1007/s00268-014-2545-8. View

18.

Szkandera J, Gerger A, Liegl-Atzwanger B, Absenger G, Stotz M, Friesenbichler J . The lymphocyte/monocyte ratio predicts poor clinical outcome and improves the predictive accuracy in patients with soft tissue sarcomas. Int J Cancer. 2013; 135(2):362-70. DOI: 10.1002/ijc.28677. View

19.

Rosenberg S . Progress in human tumour immunology and immunotherapy. Nature. 2001; 411(6835):380-4. DOI: 10.1038/35077246. View

20.

Jiang R, Cai X, Yang Z, Yan Y, Zou X, Guo L . Elevated peripheral blood lymphocyte-to-monocyte ratio predicts a favorable prognosis in the patients with metastatic nasopharyngeal carcinoma. Chin J Cancer. 2015; 34(6):237-46. PMC: 4593366. DOI: 10.1186/s40880-015-0025-7. View