The Early Predictive Value of Routine Laboratory Tests on the Severity of Acute Pancreatitis Patients in Pregnancy: a Retrospective Study

Overview

Journal Sci Rep

Specialty Science

Date 2020 Jun 24

PMID 32572085

Citations 8

Authors

Di Jin

Jixue Tan

Jingsun Jiang

Dana Philips

Ling Liu

Affiliations

Soon will be listed here.

Abstract

Acute pancreatitis in pregnancy (APIP) varies in severity from a self-limiting mild condition to a severe life-threatening condition, and its severity is significantly correlated with higher risks of maternal and foetal death. This study evaluated the early predictive value of routine laboratory tests on the severity of APIP patients. We enrolled 100 patients with APIP in West China Hospital. Initial routine laboratory tests, including the biochemistry and hematologic tests were collected within 48 hours after the onset of APIP. For predicting SAP in AP, LDH had the highest specificity of 0.879. RDW was a suitable predictive marker as it had the sensitivity of 0.882. Lower levels of triglycerides (<4.72 mmol/L) predicted mild AP of APIP, with an area under the curve (AUC) of 0.724, and a negative predictive value of 0.80. Furthermore, a risk score was calculated based on white blood cells, neutrophils, RDW, LMR and LDH, as an independent marker (adjusted odds ratio = 3.013, 95% CI 1.893 to 4.797, P < 0.001), with the highest AUC of 0.906, a sensitivity of 0.875 and a specificity of 0.828. In conclusion, the risk score we recommended was the powerful marker to aid in the early prediction of the severity of APIP patients.

Citing Articles

Assessment of early factors for identification or prediction severe acute pancreatitis in pregnancy.

Mei L, Gan Q, Hu J, Li Y, Tian R, Shi C World J Clin Cases. 2024; 12(24):5502-5512.

PMID: 39188606 PMC: 11269993. DOI: 10.12998/wjcc.v12.i24.5502.

Acute Pancreatitis in Pregnancy: A Propensity Score Matching Analysis and Dynamic Nomogram for Risk Assessment.

Tang X, Chen Y, Huang S, Jiang J, Luo B, Ren W Dig Dis Sci. 2024; 69(6):2235-2246.

PMID: 38602621 DOI: 10.1007/s10620-024-08415-8.

Early predictive value of scoring systems and routine laboratory tests in severity and prognosis of acute pancreatitis in pregnancy.

Wang Y, Qu G, Wu Z, Tian D, Yang W, Li H Therap Adv Gastroenterol. 2023; 16:17562848231167277.

PMID: 37113191 PMC: 10126706. DOI: 10.1177/17562848231167277.

Pancreatitis in Pregnancy-Comprehensive Review.

Madro A Int J Environ Res Public Health. 2022; 19(23).

PMID: 36498253 PMC: 9737239. DOI: 10.3390/ijerph192316179.

Development of a Novel Nomogram Incorporating Red Blood Cell Distribution Width-Albumin Ratio for the Prediction of 30-day Mortality in Acute Pancreatitis Patients.

Pan L, Pan S, Lei B, Hong G, Chen K Emerg Med Int. 2022; 2022:1573931.

PMID: 36478954 PMC: 9722298. DOI: 10.1155/2022/1573931.

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