Prognostic Value of Preoperative Lymphocyte-to-monocyte Ratio in Gallbladder Carcinoma Patients and the Establishment of a Prognostic Nomogram

Overview

Journal Medicine (Baltimore)

Specialty General Medicine

Date 2020 Aug 7

PMID 32756087

Citations 2

Authors

Yan Deng

Ming-Fang Xu

Feng Zhang

Xiao Yu

Xue-Wen Zhang

Zhen-Gang Sun

Shuai Wang

Affiliations

Soon will be listed here.

Abstract

The purpose of this study was to investigate the potential prognostic value of preoperative lymphocyte-to-monocyte ratio (LMR) and establishment of a prognostic nomogram in post surgical patients with gallbladder carcinoma (GBC).Receiver operating characteristic curve analysis was performed to determine the optimal cut-off value of LMR. The correlation between preoperative LMR and overall survival (OS) was analyzed using univariate and multivariate Cox regression analyses. A relevant prognostic nomogram was established.Three hundred fifteen GBC patients were retrospectively enrolled. Based on receiver operating characteristic curve analysis, the optimal cutoff value of LMR was 2.685. Patients were categorized into high-LMR group (n = 143) or low-LMR group (n = 172). Low-LMR value was significantly associated with elderly age, advanced tumor, and the performance of a palliative cholecystectomy. The results of the univariate and multivariate analyses eliminated the degree of tumor differentiation, tumor-node-metastasis stages, surgery types, and LMR as independent predictors of OS. Based on those independent predictors, a predictive nomogram for OS was generated with an accuracy of 0.848.Based on our findings, the predictive nomogram should be included in the routine assessment of GBC patients.

Citing Articles

Haematologic biomarkers and survival in gallbladder cancer: a systematic review and meta-analysis.

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Sun L, Ke X, Wang D, Yin H, Jin B, Xu H J Cancer. 2021; 12(14):4172-4182.

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