Sequence of PNL194, a 79.3-kilobase IncN Plasmid Carrying the BlaVIM-1 Metallo-beta-lactamase Gene in Klebsiella Pneumoniae

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2010 Jul 28

PMID 20660690

Citations 24

Authors

V Miriagou

C C Papagiannitsis

S D Kotsakis

A Loli

E Tzelepi

N J Legakis

L S Tzouvelekis

Affiliations

Soon will be listed here.

Abstract

The nucleotide sequence of pNL194, a VIM-1-encoding plasmid, is described in this study. pNL194 (79,307 bp) comprised an IncN-characteristic segment (38,940 bp) and a mosaic structure (40,367 bp) including bla(VIM-1), aacA7, aadA1, aadA2, dfrA1, dfrA12, aphA1, strA, strB, and sul1. Tn1000 or Tn5501 insertion within fipA probably facilitated recruitment of additional mobile elements carrying resistance genes.

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